George Clooney as Seth Gecko

Quentin Tarantino as Richard Gecko

Harvey Keitel as Jacob Fuller

Juliette Lewis as Kate Fuller

Ernest Liu as Scott Fuller

Salma Hayek Pinault as Santanico Pandemonium

Cheech Marin as Border Guard / Chet Pussy / Carlos

Danny Trejo as Razor Charlie

Tom Savini as Sex Machine

Fred Williamson as Frost

Michael Parks as Texas Ranger Earl McGraw

Brenda Hillhouse as Hostage Gloria

John Saxon as FBI Agent Stanley Chase

Marc Lawrence as Old Timer

Kelly Preston as Newscaster Kelly Houge

John Hawkes as Pete Bottoms

Tito Larriva as Titty Twister Guitarist & Vocalist

Peter Atanasoff as Titty Twister Saxophonist

Johnny Vatos Hernandez as Titty Twister Drummer

Aimee Graham as Blonde Hostage

Heidi McNeal as Red-headed Hostage

Ernest M. Garcia as Big Emilio

Greg Nicotero as Sex Machine's Buddy

Cristos as Danny

Mike Moroff as Manny

Michelle Berube as Bar Dancer

Rosalia Hayakawa as Bar Dancer

Neena Bidasha as Bar Dancer

Janine Jordae as Bar Dancer

Veena Bidasha as Bar Dancer

Jacque Lawson as Bar Dancer

Ungela Brockman as Bar Dancer

Tiffany Granath as Bar Dancer

Madison Clark as Bar Dancer

Janie Liszewski as Bar Dancer

María Díaz as Bar Dancer

Tia Texada as Bar Dancer

Michael McKay as Monster

Jake McKinnon as Monster

Walter Phelan as Monster

Wayne Toth as Monster

Cecilia Montiel as Herself

Annette Harper as Bar Dancer

Lawrence Bender as Man in Diner (Uncredited)

Robert Rodriguez as Band Member (uncredited)