Frank Welker as Scooby-Doo / Fred (voice)

Grey DeLisle as Daphne (voice)

Matthew Lillard as Shaggy (voice)

Kate Micucci as Velma (voice)

Carlos Alazraqui as Larry (voice)

Max Charles as Buddy G. (voice)

Gary Cole as Rafe (voice)

Jessica DiCicco as Desdemona Gunderson (voice)

Tania Gunadi as Carol (voice)

Eric Ladin as Kyle (voice)

Nolan North as David (voice)

Stephen Tobolowsky as Andy Gunderson (voice)

Lauren Tom as Sharon (voice)

Melissa Villaseñor as Tawny (voice)

Kari Wahlgren as Midge Gunderson (voice)

Gary Anthony Williams as Cook (voice)