John Lithgow as Don Quixote de La Mancha / Alonso Quixano

Bob Hoskins as Sancho Panza

Isabella Rossellini as The Duchess

Vanessa Williams as Dulcinea / Aldonza

Lambert Wilson as Duke

Amelia Warner as Antonia

Tony Haygarth as Barber

Peter Eyre as Priest

Lilo Baur as Teresa Panza (Sancho's wife)

James Purefoy as Carrasco

Trevor Peacock as Innkeeper

Linda Bassett as Housekeeper

Barry Stanton as Chaplain

Alun Raglan as Rodriquez

Michael Feast as Doctor

Graham Crowden as Montesino

Amparo Valle as Mother Panza (Older)

Alicia Borrachero as Mother Panza (Younger)

Ruth Sheen as 1st Wench / Young Lady

Rosemary Smith as 2nd Wench / Young Lady

Sean Gilder as Captain

Amador Pita Gonzales as Prisoner 1

Ben Thomas as Prisoner 2

John East as Prisoner 3

Larry Sheridan as Prisoner 4

Francis Magee as Ginisella de Parapille

Teté Delgado as Hostess 2nd Inn

Eileen Bell as 1st Country Girl

Ruth Silvestre as 2nd Country Girl

Manolo Caro as Shepherd

Jessica Oyelowo as 1st Handmaiden

Natasha Estelle as 2nd Handmaiden

Hannah Mosle-Hughes as Sanchina

Mike Kemp as Mayor

Rory Edwards as Duke's Man

Jorge Cadalduero as 1st Officer

Leandro Giménez as 2nd Officer

Christopher Neal as Boy Alonso

Stephen Giffen as Herald

Paco Nones as Duke's Man 2

Lucina Gil as Lady in White

Michael Culkin as 1st Monk

Timothy Bateson as 2nd Monk

Balbino Lacosta as Dentist

Victoria Navarrete Mandly as Damsel

Antonio Gil as Magician

Lloyd Williams as Giant

Guy E. Williams as Giant

Big Greg Essex as Giant

Phil Downes as Giant