Seth Rogen as Frank / Sergeant Pepper (voice)

Kristen Wiig as Brenda (voice)

Jonah Hill as Carl (voice)

Bill Hader as Firewater / Tequila / El Guaco (voice)

Michael Cera as Barry (voice)

James Franco as Druggie (voice)

Danny McBride as Honey Mustard (voice)

Craig Robinson as Grits (voice)

Paul Rudd as Darren (voice)

Nick Kroll as Douche (voice)

David Krumholtz as Kareem Abdul Lavash (voice)

Edward Norton as Sammy Bagel Jr. (voice)

Salma Hayek Pinault as Teresa Taco (voice)

Anders Holm as Troy (voice)

Scott Underwood as Gum / Twink / Krinkler's Chips / Pizza (voice)

Sugar Lyn Beard as Baby Carrot / Cookies (voice)

Conrad Vernon as Toilet Paper / Sauerkraut / Catcall Sausage / Grape #1 / Beer Can / Pop Bottle (voice)

Ian James Corlett as Apple / Tickilish Licorice / Relish / Bag of Dog Food (voice)

Michael Daingerfield as Chunk Munchers Cereal / Light Bulb / Indian Chutney (voice)

Jason Simpson as Plum #2 / Beer Keg / Fat Guy / Fit Man (voice)

Vincent Tong as Pislitz Chips / Juice Box / Jamaican Rum (voice)

Karen E. Wright as Diner Waitress

Lauren Miller Rogen as Camille Toh / Tampon (voice)

Sam Vincent as Old Pork Sausage / Refried Beans / Sandwich / Pop Tart / Licorice Rope (voice)

Greg Tiernan as Potato / Noodle Soup (voice)

Brian Dobson as Italian Tomato / Lettuce (voice)

Harland Williams as Ketchup / Drug Dealer / Baba Ganoush (voice)

Alistair Abell as Mariachi Salsa / Gefilte Fish (voice)

Iris Apatow as Berry Good Candies / Grape #3 / Coconut Milk (voice)

Michael Dobson as Queso (voice)

Ian Hanlin as Beet (voice)

Maryke Hendrikse as Popped Cherry Mixer / Plum #1 / Loretta Bun / Frozen Fruitz (voice)

Nicole Oliver as Sally Bun / Ice Cream / Watermelon / Female Shopper #1 (voice)

Kelly Sheridan as Roberta Bun / Grape #2 / Female Shopper #2 (voice)

Meat Loaf as Meatloaf (voice) (uncredited)