Melissa McCarthy as Tammy

Susan Sarandon as Pearl

Kathy Bates as Lenore

Mark Duplass as Bobby

Gary Cole as Earl

Allison Janney as Deb

Dan Aykroyd as Don

Sandra Oh as Susanne

Nat Faxon as Greg

Toni Collette as Missi

Ben Falcone as Keith Morgan

Sarah Baker as Becky

Rich Williams as Larry

Steve Little as Jet Ski Rental Guy

Dakota Lee as Kathleen

Mark L. Young as Jesse

Mia Rose Frampton as Karen

Steve Mallory as Cashier

Big Al Hall as Possum Creek Bluegrass Band

Jones Smith as Possum Creek Bluegrass Band

Joe Baxter as Possum Creek Bluegrass Band

Benjamin Chontos as Possum Creek Bluegrass Band

Sean Gould as Possum Creek Bluegrass Band

Keith Welborn as DJ

Oscar Gale as Javier

Justin Smith as Paramedic

Willie Hill as Prison Guard

Zach Hanner as Man at Blue Post Bar-B-Que

Jason Vail as Man at Blue Post Bar-B-Que

Leon Lamar as Old Man with Walker

Larry Dorf as Officer Mannis

Ricky Muse as Officer Curtis

Barbara Weetman as Officer Carty

William Flaman as La Grange Bail Cop

Rey Hernandez as Cop at Lakehouse

Penn Holderness as News Anchor

Michelle Li as News Reporter

Raven Angeline Whisnant as Charlotte

Damon Jones as Jerry Miller

Sandy McCarthy as Old Lady Leaving a Bar

Margo Passas as Old Lady Leaving a Bar

Sheila Brothers as Connie (uncredited)

Rob Springer as Gene the Cook (uncredited)

Cricket Ellis as Lunchroom Lady (uncredited)

Kaitlyn Christian as Canoe Teen (uncredited)

J.R. Rodriguez as Kentucky Trooper (uncredited)

Michelle Rivera Huckaby as Arresting Cop (uncredited)

David Andrew Nash as Morningside Guard (uncredited)