Sandra Bullock as Sarah Ashburn

Melissa McCarthy as Shannon Mullins

Demián Bichir as Hale

Marlon Wayans as Levy

Michael Rapaport as Jason Mullins

Jane Curtin as Mrs. Mullins

Spoken Reasons as Rojas

Dan Bakkedahl as Craig

Taran Killam as Adam

Michael McDonald as Julian

Thomas F. Wilson as Captain Woods

Peter Weireter as SWAT Team Leader

John Ross Bowie as NY Agent

William Xifaras as Tough Guy #1

Cary 'Big Shug' Guy as Tough Guy #2

Erica Derrickson as Prostitute

Tony Hale as John

Deirdre Horgan as Police Dispatch (voice)

William Ambrose Kennedy as Desk Sergeant

Tony V. as Precinct Officer

Amanda Good Hennessey as Woman with Kid

Patty Ross as Drunk Woman

Kaitlin Olson as Tatiana

Ellen Becker Gray as Tatiana's Mother

Andy Buckley as Robin

Don Orsillo as Baseball Announcer

Adam Ray as LeSoire

Chris Gethard as Chris Gethard

Dane Aska as Club Ekko Bartender

Joey McIntyre as Peter Mullins

Michael Tucci as Mr. Mullins

Bill Burr as Mark Mullins

Nate Corddry as Michael Mullins

Jessica Chaffin as Gina

Jamie Denbo as Beth

Miriam Tolan as Pathologist

Alexis Garcia as Drug Dealer in Paint Factory

Raw Leiba as Paint Factory Henchman

Ben Falcone as Blue Collar Man

Joe Stapleton as O'Flanagan's Bartender

Steve Bannos as Wayne

Fletcher McTaggart as Choking Man

Zach Woods as Paramedic

Joe Garland as Boston Agent

Thomas B. Devlin as Boston Agent

Benjamin Evett as Boston Agent

Elliot Santiago as Dealer

Mitch Silpa as Dealer

Luis Da Silva, Jr. as Dealer

Steve Grodewald as Dealer

Katie Dippold as ER Nurse

Kelby Turner Akin as Orderly

Lance Norris as Scruffy Bar Patron

Paul Feig as Doctor (uncredited)

John Franchi as Bar Patron (uncredited)

Colleen Kelly as Detective (uncredited)

Brandon Richardson as Factory Worker