George Clooney as Ryan Bingham

Vera Farmiga as Alex Goran

Anna Kendrick as Natalie Keener

Sam Elliott as Maynard Finch

Amy Morton as Kara Bingham

Jason Bateman as Craig Gregory

Melanie Lynskey as Julie Bingham

J.K. Simmons as Bob

Danny McBride as Jim Miller

Zach Galifianakis as Steve

Tamala Jones as Karen Barnes

Adhir Kalyan as Fired IT worker

Keri Maletto as Software convention geek

Steve Eastin as Samuels

Adrienne Lamping as Tammy

Chris Lowell as Kevin

Erin McGrane as Dianne

Marvin Young as Young MC

Cut Chemist as Conference DJ

Meagan Flynn as Flight Attendant

Dustin Miles as Ned

Tamara Tungate as Club Hostess

Laura Ackermann as Check-in Lady

Meghan Maguire as Business Woman

Courtney Kling as Airport Clerk

Matt O'Toole as Alex's Husband

Alan David as Hilton Clerk

Cari Mohr as Purser

Jerry Vogel as San Francisco Manager

Jeff Witzke as Goalquest Host

Dave Engfer as Software Dude

Paul Goetz as Rental Car Assistant

Michele Reitman as Conference Worker

Jennifer Nitzband as Wedding Cousin

Bill Yancy as Wedding Pastor

John Mebruer as Band Leader

Ellen Gutierrez as Wedding Coordinator

Adam Rose as Makeout Dave

Kevin Pilla as Terminated Employee

Kelly Bertha as Terminated Employee

Cozy Bailey as Terminated Employee

Lamorris Conner as Terminated Employee

Deborah L. Norman as Terminated Employee

Casey Bartels as Terminated Employee

Bill Phelan as Terminated Employee

Arthur Hill as Terminated Employee

Patricia Allison as Terminated Employee

David F. Rybicki as Terminated Employee

Andy Glantzman as Terminated Employee

Kevin D. Lewis as Terminated Employee

Jo Michelle Favaro as Terminated Employee

Stephanie Janiunas as Terminated Employee

Thomas M. Martilotti as Terminated Employee

Erin Welsh-Krengel as Terminated Employee

Marlene Gorkiewicz as Terminated Employee

Mark Sommers as Terminated Employee

Wilbur Weidlich as Terminated Employee

Grace Smith as Terminated Employee

Scott Lapinski as Terminated Employee

George Batten as Terminated Employee