Frank Welker as Fred / Scooby-Doo (voice)

Matthew Lillard as Shaggy (voice)

Mindy Cohn as Velma (Voice)

Grey DeLisle as Daphne (voice)

Dee Bradley Baker as C.L. Magnus / Mr. Burger (voice)

Diedrich Bader as Mrs. Vanders (voice)

Susanne Blakeslee as Townswoman (voice)

Eric Bauza as Daphanatic / Rock Dude (voice)

Jeff Bennett as Iago / Schmidlap (voice)

Kevin Michael Richardson as Cuthbert Crawley / Inspector Krunch (voice)

Candi Milo as Gypsy / Lila (voice)

Corey Burton as Baron Basil (voice)

Fred Tatasciore as Frankencreep (voice)

John Stephenson as Roger (voice) (archive footage)

Casey Kasem as Shaggy Rogers (voice) (archive footage)