Adrienne Barbeau as Virtual Narrator (voice)

Cody Longo as Agent Jae Novak

Cortney Palm as Agent Toria Boon

Michael Berryman as Crau

Barbara Crampton as Dr. Karen Redmane

Sid Haig as Icicle Killer

Lindsay Hartley as Balthoria

Kane Hodder as Sieg

Lloyd Kaufman as Dr. Chalice

Camille Keaton as Kristi Boon

R.A. Mihailoff as Prison Badass Leader

Bill Moseley as Giger

Bill Oberst Jr. as Satan Creator

Felissa Rose as Dr. Angela Freeman

Tony Todd as The Farmer Asa

Dee Wallace as Dr. Eileen Fletcher

Vernon Wells as Nela

Sean Whalen as Satan

Tiffany Shepis as Doctor Peter

Debbie Rochon as Leatherlace

Brinke Stevens as Doctor Banks

Beverly Randolph as Doctor Tarman

Elissa Dowling as Doctor Rowena

Yan Birch as Doctor Phibes

Larry Zerner as Shelly the Prop Man

Gunnar Hansen as Albert Kenny

Michael Kean as Prisoner

Tony Moran as Death House Inmate

Gabrielle Stone as Linz Haddon

Sarah French as Icicle Killer's Victim (uncredited)

Maxine Wasa as Homeless Girl

Bernhard Forcher as Antichrist

Michael Guarnera as Commander Bradshaw

Steven Chase as Corporal Salerno

Anthony Hoang as Subordinate Soldier

Steve Nappe as Bijhead

Greg Pronko as Rioting Prisoner

Lauren Compton as Dr. Logan Harrison

Dmitri Schuyler-Linch as Bennett's Cast (uncredited)

Danny Trejo as Inmate (uncredited)

Mark Mackner as Masked Antichrist

Robert Kestler as Guard

Lou Consolo as Rioting Prisoner (uncredited)