Nia Vardalos as Toula Portokalos-Miller

John Corbett as Ian Miller

Elena Kampouris as Paris Miller

Michael Constantine as Kostas "Gus" Portokalos

Lainie Kazan as Maria Portokalos

Andrea Martin as Aunt Voula

Gia Carides as Nikki Portokalos

Joey Fatone as Angelo

Louis Mandylor as Nick Portokalos

Alex Wolff as Bennett

Bess Meisler as Mana-YiaYia

Bruce Gray as Rodney Miller

Fiona Reid as Harriet Miller

Ian Gomez as Mike

Jayne Eastwood as Mrs. White

Rob Riggle as Northwestern Rep

Mark Margolis as Panos

Rita Wilson as Anna

John Stamos as George

Jeanie Calleja as Ilaria

Michael Sofos as Costa

Stavroula Logothettis as Athena

Leonidas Castrounis as Aristotle

Peter Tharos as Yianni

Harper Gunn as Paris at 4

Hershel Blatt as Tommy

Tannis Burnett as Edie

Kathryn Greenwood as Marge

Teresa Pavlinek as Dominique

Aniela Kurylo as Physical Therapist

Sam Moses as Kaveh

Roger Wong as Pim

Alec Stockwell as Baird

Gerry Mendicino as Uncle Taki

Kathryn Haggis as Marianthi

Kolton Stewart as Clifford

Theodore Paraskevopoulos as Priest

Ethan Pugiotto as Theadore

Ashleigh Rains as Wedding Planner

Chrissy Paraskevopoulos as Jennie

Maria Vacratsis as Aunt Freida

Julia Gartha as Tiahn

Jeff White as Patrick

Constantine Vardalos as Chanter

Lauren Saarimaki as Elizabeth

Robert Bellissimo as Toula's Nephew (uncredited)

Dave Reachill as Teacher (uncredited)

Maxillian Grimm as Chef (uncredited)

Christopher D. Lindsay as Student (uncredited)