Avery Brooks as Uncle Tom

Kate Burton as Ophelia

Bruce Dern as Augustine St. Claire

Paula Kelly as Cassy

Phylicia Rashād as Eliza

Kathryn Walker as Marie St. Claire

Edward Woodward as Simon Legree

George Coe as Mr. Shelby

Frank Converse as Trader

Albert Hall as Quimbo

Jenny Lewis as Evangeline "Little Eva" St. Claire

Troy Byer as Emmeline

Shirley Jo Finney as Aunt Chloe

Samuel L. Jackson as George

Endyia Kinney-Sterns as Topsy

Lane Trippe as Mrs. Shelby

Irma P. Hall as Mammy

Jerry Haynes as Dr. Phillips

Gil Glasgow as Loker

Harlan Jordan as Deputy

Paul Osborne as Sambo

Sami Chester as Sam

Rickey Pierre as Andy

Gerald Hopkins as Christopher at 17

Eliott Keener as Auctioneer

B.J. Hopper as Simeon

Robert Adams as Phineas Fletcher

Carol Sutton as Lucy

James Williamson as Mark

Elaine Partnow as Mrs. Smythe

Rhashell Hunter as Jenny

Marjorie Rynearson as Rachel

Robert Graham as Elias

Bill Bolender as Trader

Cris Loveless as Young Christopher

Alta Cannaday as Bea

Jean Mayre as Woman on Boat

Harold De Marrero as Man on Boat

Walter Breaux as Adolphe

William Ramsey as Jimmy

Duane Dunkley as Tom's Son

Ray Spruell as Harper