Wesley Snipes as Blade

Stephen Dorff as Deacon Frost

Kris Kristofferson as Whistler

N'Bushe Wright as Karen

Donal Logue as Quinn

Udo Kier as Dragonetti

Arly Jover as Mercury

Traci Lords as Racquel

Kevin Patrick Walls as Krieger

Tim Guinee as Curtis Webb

Sanaa Lathan as Vanessa

Eric Edwards as Pearl

Donna Wong as Nurse

Carmen Thomas as Senior Resident

Shannon Lee as Resident

Kenny Johnson as Heatseeking Dennis

Clint Curtis as Creepy Morgue Guy

Judson Scott as Pallantine

Sidney S. Liufau as Japanese Doorman

Keith Leon Williams as Kam

Andray Johnson as Paramedic

Stephen R. Peluso as Paramedic

Marcus Aurelius as Pragmatic Policeman

John Enos III as Blood Club Bouncer

Eboni 'Chrystal' Adams as Martial Arts Kid

Lyle Conway as Reichardt

Freeman White as Menacing Stud

D.V. DeVincentis as Vampire Underling

Marcus Salgado as Frost's Goon

Esau McKnight as Frost's Goon

Erl Van Douglas as Von Esper

Matt Schulze as Crease

Lennox Brown as Pleading Goon

Yvette Ocampo as Party Girl

Irena Stepić as Slavic Vampire Lord

Jenya Lano as Russian Woman

Levan Uchaneishvili as Russian Vampire

Chris Casamassa as Vampire (uncredited)

Ron Cobert as Vampire (uncredited)

Laura Cordova as Vampire (uncredited)

Nikki DiSanto as Vampire Victim (uncredited)

Ryan Glorioso as Blood Bath Vampire (uncredited)

Al Goto as Henchman (uncredited)

Mark Heenehan as Club Patron (uncredited)

Steven Ho as Frost's Goon (uncredited)

Jeff Imada as Henchman (uncredited)

Diana Lee Inosanto as Blood Bath Vampire (uncredited)

Steven D. Ito as Henchman (uncredited)

Elliott James as Blood Club (uncredited)

Ted King as Vampire at Rave (uncredited)

Henry Kingi as Bartender (uncredited)

Will Leong as Henchman (uncredited)

David Matthiessen as Vampire (uncredited)

Stephen Norrington as Vampire (uncredited)

Gerald Okamura as Vampire (uncredited)

Frankie Ray as Vampire Lord (uncredited)

Simon Rhee as Henchman (uncredited)

Michael Stumpf as Sword Thrower (uncredited)

Jen Taylor as Vampire (uncredited)