Wesley Snipes as Blade

Kris Kristofferson as Whistler

Ron Perlman as Reinhardt

Leonor Varela as Nyssa

Norman Reedus as Scud

Thomas Kretschmann as Damaskinos

Luke Goss as Nomak

Matt Schulze as Chupa

Danny John-Jules as Asad

Donnie Yen as Snowman

Karel Roden as Kounen

Marit Velle Kile as Verlaine

Tony Curran as Priest

Daz Crawford as Lighthammer

Santiago Segura as Rush

Samuel Le as Jigsaw

Marek Vašut as Golem

Pete Lee-Wilson as Blood Bank Doctor / Reaper

Paul Kasey as Blood Bank Guard / Reaper

Andrea Miltner as Blood Bank Nurse

Ladislav Beran as Drug Dealer

Jiří Maria Sieber as Blood Bank Guard

Bridge Markland as Vampire with Exposed Spine

Jamie Wilson as Reaper

Stuart Luis as Reaper

Ladislav Mohyla as Reaper

Jan Malík as Reaper

Jan Révai as Reaper

Mário Wild as Reaper

Tomáš Böhm as Reaper

Zdenek Bubák as Reaper

Jan Loukota as Reaper

Jan Bursa as Reaper

Petr Krusalnicky as Reaper

Jaroslav Misek as Reaper

Karel Vávrovec as St. Cloud

Jaroslav Peterka as Choad

Miloš Kulhavý as Little G

Ivan Mareš as Tea Bag

Lennox Brown as Man in London Porno Shop

André Hyde-Braithwaite as Young Blade

Pavel Cajzl as Moscow Vampire (uncredited)

Olga Lounová as Prostitute (uncredited)

Stephen R. Peluso as Paramedic (uncredited)

John Salvitti as Moscow Vampire Attacking Blade (uncredited)

Kenji Tanigaki as Moscow Vampire Attacking Blade (uncredited)

Michael Woods as Moscow Vampire Attacking Blade (uncredited)