Brad Dourif as Sam

Cynthia Bain as Lisa Wilcox

Jon Cypher as Dr. Marsh

William Prince as Lew Orlander

Melinda Dillon as Nina

Dey Young as Rachel

Tegan West as Springer

Michael Keys Hall as Dr. Cagney

Dale Dye as General

Dick Butkus as Lt. General

Joe Mays as Dr. Persons

Stacy Edwards as Peggy Bell

Brian Bremer as Brian Bell

Frank Whiteman as Young Orlander

Judy Prescott as Student Director

Judy Behr as School Nurse

Betsy Thomas as Nurse at Hospital

André de Toth as Vandenmeer (uncredited)

John Landis as Radio Technician

Jaime Alba as Walter

Mark Roberts as Dr. Simpson

Dick Warlock as Mr. Fitzpatrick

Judith Jones as Jennifer

William Forward as Scientist

Ron Blair as Maitre 'D

Mimi Wearn as Vicky

Sandy Ignon as Doctor in 50's

Nick Gambella as Student in Theater

Patricia Gallagher Layton as Maid

Barbara Leary as Amy Whitaker

Paul Barresi as Hospital Guard

George Buck Flower as Preacher on Radio (voice)

Tobe Hooper as Cigar Smoking Diner Patron

Patrick Brock as Paramedic (uncredited)