Ben Stiller as Greg Focker

Robert De Niro as Jack Byrnes

Teri Polo as Pam Byrnes

Blythe Danner as Dina Byrnes

Nicole DeHuff as Debbie Byrnes

Jon Abrahams as Denny Byrnes

Owen Wilson as Kevin Rawley

James Rebhorn as Dr. Larry Banks

Tom McCarthy as Dr. Bob Banks

Phyllis George as Linda Banks

Kali Rocha as Flight Attendant

Bernie Sheredy as Norm the Interrogator

Judah Friedlander as Pharmacy Clerk

Peter Bartlett as Animal Shelter Worker

John Elsen as Chicago Airport Security

Mark Hammer as Hospital Patient

Amy Hohn as Ticket Agent

William Severs as Father O'Boyle

John Fiore as Kinky

Marilyn Dobrin as Kali Rocha

Marci Reid as Traveler

Frank Santorelli as Courier

Russell Hornsby as Late Night Courier

Patricia Cook as Little Girl

Cody Arens as Little Boy

Cole Hawkins as Little Boy

Spencer Breslin as Little Boy

Ina Rosenthal as Wedding Worker

Kim Rideout as Nurse

Kresh Novakovic as Airport Policeman

John Joseph Gallagher as Cop

G.A. Aguilar as Cop

Lynn Ann Castle as Security Guard