Ben Stiller as Larry Daley

Amy Adams as Amelia Earhart

Owen Wilson as Jedediah Smith

Hank Azaria as Kahmunrah / The Thinker / Abe Lincoln

Robin Williams as Theodore Roosevelt

Christopher Guest as Ivan the Terrible

Alain Chabat as Napoleon Bonaparte

Steve Coogan as Octavius

Ricky Gervais as Dr. McPhee

Bill Hader as George Armstrong Custer

Jon Bernthal as Al Capone

Patrick Gallagher as Attila the Hun

Jake Cherry as Nicky Daley

Rami Malek as Ahkmenrah

Mizuo Peck as Sacajawea

Kerry van der Griend as Neanderthal #1

Matthew Harrison as Neanderthal #2

Rick Dobran as Neanderthal #3

Randy Lee as Hun #1

Darryl Quon as Hun #2

Gerald Wong as Hun #3

Paul Cheng as Hun #4

Jay Baruchel as Sailor Joey Motorola

Mindy Kaling as Docent

Keith Powell as Tuskegee Airman #1

Craig Robinson as Tuskegee Airman #2

Samuel Patrick Chu as Teenage Boy #1

Augustus Oicle as Teenage Boy #2

Kai James as Teenage Boy #3

Clint Howard as Air and Space Mission Control Tech #1

Matty Finochio as Air and Space Mission Control Tech #2

George Foreman as George Foreman

Josh Byer as Capone Gangster #1

Sophie Levy as Young Girl #1

Tess Levy as Young Girl #2

Christina Schild as 'American Gothic' Woman

Robert Thurston as 'American Gothic' Farmer

Alberta Mayne as Kissing Nurse

Clifton MaCabe Murray as Kissing Sailor

Caroll Spinney as Oscar the Grouch (voice)

Thomas Morley as Darth Vader

Dan Joffre as Town Car Driver

Dave Hospes as Astronaut

Regina Taufen as New York Reporter

Shawn Levy as Infomercial Father

Joe Jonas as Cherub #1 (voice)

Kevin Jonas as Cherub #2 (voice)

Nick Jonas as Cherub #3 (voice)

Eugene Levy as Albert Einstein (voice)

Brad Garrett as Easter Island Head (voice)

Ed Helms as Larry Daley's Assistant (uncredited)

Jonah Hill as Brundon the Security Guard (uncredited)

Thomas Lennon as Wilbur Wright (uncredited)

Crystal the Monkey as Dexter / Able (uncredited)