Marion Cotillard as Leonora Orantes

Matt Damon as Mitch Emhoff

Laurence Fishburne as Ellis Cheever

Jude Law as Alan Krumwiede

Kate Winslet as Erin Mears

Jennifer Ehle as Ally Hextall

Gwyneth Paltrow as Beth Emhoff

Bryan Cranston as Lyle Haggerty

Elliott Gould as Ian Sussman

Chin Han as Sun Feng

John Hawkes as Roger

Anna Jacoby-Heron as Jory Emhoff

Sanaa Lathan as Aubrey Cheever

Demetri Martin as David Eisenberg

Armin Rohde as Damian Leopold

Enrico Colantoni as Dennis French

Larry Clarke as Dave

Monique Gabriela Curnen as Lorraine Vasquez

Daria Strokous as Irina

Rick Uecker as Minnesota Health

Jamie Newell as Siphon Woman (uncredited)

Griffin Kane as Clark Morrow

Rebecca Spence as Jon Neal's Wife

Yoshiaki Kobayashi as Japanese Bus Man

Teri McEvoy as School Nurse

Sue Redman as ER Nurse #1

Teri Campbell as ER Nurse #2

Stef Tovar as Dr. Arrington

Mary Jo Faraci as Social Worker

Grace Rex as Carrie Anne

Joseph Anthony Foronda as WHO Official

Annabel Armour as Beth's Mother

Jim Ortlieb as Funeral Director

Kara Zediker as Elizabeth Nygaard

Laura Fisher as Sick Lady

Mary Beth Dolan as Nun

Dan Flannery as Hextall's Father

Jason Babinsky as Shivering Man

Howie Johnson as Morgue Worker

Sanjay Gupta as Sanjay Gupta

Chui Tien-You as Li Fai

Josie Ho as Li Fai's Sister

Steven Soderbergh as John Neal (voice, uncredited)

Phillip James Brannon as Paramedic

David Lively as Minnesota Medical Examiner

Andrew White as Assistant Medical Examiner

Ira Blumen as Helpful Doctor

Scott Stangland as Minnesota Health #1

Jimmy Chung as Minnesota Health #2

Tara Mallen as Minnesota Health #4

John Hines as AIMM Employee #1

Joshua Weinstein as AIMM Employee #2

Sarah Charipar as AIMM Employee #3

Mark Czoske as AIMM Employee #4

Dan Aho as Aaron Barnes

Hee-Wan Kwon as Japanese Official

Phil Tang as Village Man #1

Robert Chi as Village Man #2

Blair Robertson as Sussman's Assistant

Randy Lowell as Hedge Fund Man in Park

Pete Sack as TV Anchor

Brian J. O'Donnell as Andrew

Kwok-Wah Wong as Chinese Health Official #1

Raymond Tsang Chau-Ming as Chinese Health Official #2

Josh Pollock as Coughing Man

Peter A Kelly as National Guardsman

Thomas Gebbia as Man with Megaphone

Dan Sanders-Joyce as Home Invasion Thug

Joshua Seiden as Anthony

Jim Anderson as Police Officer (uncredited)

Bambadjan Bamba as Dread (uncredited)

Rodolfo C Barrios as Sick Guy (uncredited)

Bryan Basil as Senate Staffer (uncredited)

Raphael Bonacchi as Police Officer (uncredited)

Ahmed Boulane as Doctor Haddad (uncredited)

Liz Clare as Vaccine Recipient (uncredited)

Rashida Clendening as Interviewee (uncredited)

David Cohen as News Reporter (uncredited)

James Anthony Cotton as Tough Guy (uncredited)

Duke Czlonka as National Guard Sergeant (uncredited)

Andrew Dasz as Airport Passager (uncredited)

Joe DeBartolo as Food Drop Recipient (uncredited)

Eduardo Ambriz DeColosio as Interviewee (uncredited)

Amanda Dyar as Vaccinated Citizen (uncredited)

Ryan Ebert as Sick Person (uncredited)

Shannon Edwards as Michael Giannes - Minnesota Health Department (uncredited)

Anas El Baz as Ahraf (uncredited)

Olivia Francessca as Nurse (uncredited)

Logan Fry as Washington D.C. Lobbyist (uncredited)

Kenley Gaffke as Vaccine Patient (uncredited)

Christian Heep as Reporter (uncredited)

Alex Hill III as Press Room Reporter (uncredited)

John Hoogenakker as Rafik's Lawyer (uncredited)

Matt Iwinski as Photographer (uncredited)

Sarah Kliban as Interviewee (uncredited)

Iris Kohl as Reporter (uncredited)

Suzanne Lang as ER Nurse (uncredited)

Elester Latham as Doctor (uncredited)

Ina Lereine as Pedestrian (uncredited)

Seth Leslie as Stage Performer (uncredited)

Josiah Lyricq as Protestor (uncredited)

Mino Mackic as Airport Businessman (uncredited)

Carl Marino as Pharmacy Fighter (uncredited)

Mary Lu Marr as Physician (uncredited)

James Mastel as FBI Agent (uncredited)

Timothy W. Mather as Print Journalist (uncredited)

Thomas McCormick as Photographer (uncredited)

Dave McNulty as Doctor in Lobby (uncredited)

E. Roger Mitchell as Driver (uncredited)

Paul D. Morgan as Hazmat Doctor (uncredited)

Jesse Muick as Vaccine Recipient (uncredited)

Larry Nazimek as CDC Employee (uncredited)

Andrew Nitzke as Epidemic Victim (uncredited)

Matthew Parry-Jones as Sick Child (uncredited)

Eric Pierson as Driver (uncredited)

Steven Potts as Sick Man (uncredited)

Steven James Price as Lt. Col Ginsberg (uncredited)

Kyle Quesnoy as Redhead Interviewee (uncredited)

Brandi Quinn as Sickly Victim (uncredited)

Kenya Robertson as Waitress (uncredited)

Joshua Rollins as Reporter (uncredited)

Sandy Rouge as Medical Staff (uncredited)

Helen Sadler as Polish Maid (uncredited)

Peggy Sandow as Sick Woman (uncredited)

Jane Santos as Survivor (uncredited)

Hester Schell as Epidemic Victim (uncredited)

Jon Komp Shin as On Air News Reporter San Francisco (uncredited)

Walt Sloan as Hospital Physician (uncredited)

Ylian Alfaro Snyder as Sick Citizen (uncredited)

Joshua Squire as Vaccine Patient (uncredited)

January Stern as Congress Woman (uncredited)

Michael T Stewart as Citizen (uncredited)

Thomas W. Stewart as Doctor (uncredited)

Audra Todd as CDC Employee (uncredited)

Giota Trakas as Reporter (uncredited)

Ken Venzke as On Air Reporter San Francisco Channel 7 (uncredited)

Abby Wait as Girl In Cafe (uncredited)

Amr Waked as Rafik (uncredited)

James D. Weston II as FBI Agent (uncredited)

Roger Wiggins as CDC Employee (uncredited)

Robert A. Young as Capital Police (uncredited)

Bobby Watson as Dying Man (uncredited)

Jeff Mosley as Doctor (uncredited)

Wong Kam-Tong as Chef