Alec Baldwin as Adam

Geena Davis as Barbara

Winona Ryder as Lydia

Catherine O'Hara as Delia

Jeffrey Jones as Charles

Michael Keaton as Betelgeuse

Glenn Shadix as Otho

Sylvia Sidney as Juno

Patrice Martinez as Receptionist

Dick Cavett as Bernard

Robert Goulet as Maxie Dean

Maree Cheatham as Sarah Dean

Susan Kellermann as Grace

Carmen Filpi as Messenger

Annie McEnroe as Jane Butterfield

Rachel Mittelman as Little Jane

Hugo Stanger as Old Bill

Maurice Page as Ernie

J. Jay Saunders as Moving Man #1

Mark Ettlinger as Moving Man #2

Cindy Daly as 3-Fingered Typist

Douglas S. Turner as Char Man

Gary Jochimsen as Dumb Football Player

Bob Pettersen as Dumb Football Player #2

Duane Davis as Very Dumb Football Player

Simmy Bow as Janitor

Adelle Lutz as Beryl

Tony Cox as Preacher

Jack Angel as Preacher (voice)

Charles Schneider as The Hanging Man (uncredited)