Jenifer Lewis as Jackie Washington

Tim Curry as Edward Whatsett St. John

T.V. Blake as Antandra Washington (Jackie's Daughter)

Tangie Ambrose as Shaniqua Summers Wells (Jackie's Daughter)

Whoopi Goldberg as Nurse Ethyl Washington Rue Owens (Jackie's Sister)

Robert Bailey Jr. as Wilson Wells (Jackie's Grandson)

Tom Arnold as Marvin Pritz (Jackie's Former Manager)

Loretta Devine as Snookie Tate (Jackie's Childhood Friend)

Julie Hagerty as Pammy Dunbar (Infomercial Host)

David Hyde Pierce as Perry (The Deaf Rehearsal Pianist)

Kathy Najimy as Lola Molina (Jackie's Stalker)

Isabel Sanford as Miss Krumes (Jackie's Play Mama)

JoBeth Williams as Jo Face (Jackie's Vocal Coach)

Mary Wilson as Vesta Crotchley (Jackie's Third Grade Teacher)

Reynaldo Rey as Cadillac Johnson (Retired Pimp)

Loren Freeman as Kim (Jackie's Costume Designer)

Derrick Jones as Peaches Yancy (Still Photos)

Richard Lawson as Milkman Summers (Jackie's Ex-Husband #1)

Patti Austin as Patti Austin (Gospel Singer at Peaches' Funeral)

Kyla Pratt as Little Jackie Washington

Lori Harmon as Angela Scotorcio (Body Double)

Johnny Brown as Rev. Eustace Barnett (Pastor, Kinloch Baptist Temple)

Alan Blumenfeld as Ivan (Theatre Manager)

Charles Barkley as Charles Barkley

Diahann Carroll as Diahann Carroll

Eddie Cibrian as Eddie Cibrian

Jackie Collins as Jackie Collins

Don Cornelius as Don Cornelius

Taylor Dayne as Taylor Dayne

Melissa Etheridge as Melissa Etheridge

Kathy Griffin as Kathy Griffin

Sean Hayes as Sean Hayes

Ricki Lake as Ricki Lake

Howie Mandel as Howie Mandel

Camryn Manheim as Camryn Manheim

Penny Marshall as Penny Marshall

Bette Midler as Bette Midler

Liza Minnelli as Liza Minnelli

Rosie O'Donnell as Rosie O'Donnell

Dolly Parton as Dolly Parton

Donna Pescow as Donna Pescow

Chris Rock as Chris Rock

Eva Marie Saint as Eva Marie Saint

Grace Slick as Grace Slick

Robert Townsend as Robert Townsend

Bruce Vilanch as Bruce Vilanch

Robert Cesario as Anthony (Paranoid Fan)

Dee Freeman as Tired Woman

Freez Luv as Larry (Die-Hard Fan)

Cynthia Palmer as Doris (Confused Fan)

Ashli Amari Adams as Inquisitive Kid

David Alexander as Stage Foreman

Gary Clancy as Sound Man - St. John's Crew

John Cook as Dancer

Joey Gaynor as Camera Man - St. John's Crew

Jason Kravits as Wimpy Bald Man

Rudy Ray Moore as Bad Guy in Coco Movie

Art Palmer as Dancer

Regan Patno as Dancer

Lance Taylor as Hostage

Jerald Vincent as Dancer

Angela Wright as Church Lady

Sophia Santi as Anti-Fur Protester #1

Kyle Armour as Anti-Fur Protester #2

Suzanne Suter as Anti-Fur Protester #3

Elaine Ward as Anti-Fur Protester #4

Brian Nahas as Anti-Fur Protester #5

Julia Dion as Anti-Fur Protester #6

Scot Zeller as Love Goddess Dancer #1

Brian Elfand as Love Goddess Dancer #2

Paul Terrell Clayton as Musician #1

Gene Ryals as Musician #2

Ski Carr as Bass Player

Rae Ritke as Reporter #1

Terrence Flack as Hospital Reporter

Tony Brubaker as Fight Biker

Danny Epper as Fight Biker

Bennie Moore as Fight Biker

Manny Perry as Fight Biker

Scott L. Schwartz as Fight Biker

Craig Shugart as Fight Biker