Michael Keaton as Bob Jones

Nicole Kidman as Gail Jones

Bradley Whitford as Paul Ivanovich

Queen Latifah as Theresa

Michael Constantine as Bill Ivanovich

Rebecca Schull as Rose Ivanovich

Mark Lowenthal as Dr. Mills

Lee Garlington as Carol Sandman

Toni Sawyer as Doris

Haing S. Ngor as Mr. Ho

Romy Rosemont as Anya Stasiuk

Danny Rimmer as Young Bobbie

Richard Schiff as Young Bill Ivanovich

Ruth de Sosa as Young Rose Ivanovich

Stephen Taylor Knott as Young Paul Ivanovich

Andrew Camuccio as Baby Brian

Brian Camuccio as Baby Brian

Colby Garabedian as Little Boy Brian

Mary Ann Thebus as Miss Morgenstern

Brenda Strong as Laura

Rudi Davis as George

Mark Holton as Sam

Lissa Walters as Deborah

Bruce Jarchow as Walter

Jane Morris as Dorothy

Kenneth Tigar as Dr. Califano

Ray Reinhardt as Dr. Altman

Frank DiElsi as Arnold Sherman

Billy L. Sullivan as Rollercoaster Boy

Michael Gallagher as Rollercoaster Friend

Nora Taylor as Little Girl

Dianne B. Shaw as Detroit Mother

Sondra Rubin as Aunt Sophia

Sylvia Kauders as Aunt Tekla

Sharon Conley as Lida Stasiuk

James R. Sweeney as Nestor Stasiuk

Vasek Simek as Uncle Henry

Magda Harout as Aunt Sonia

Mark Zingale as Delivery Man

Jonathan Fish as Delivery Man

Jennifer Flackett as Childbirth Teacher

Gary A. Rubin as Man at Wedding

Susan Breslau as Guest at Wedding

Wendy Sax as Guest at Wedding

Charlotte Zucker as Guest at Wedding

Blanche Rubin as Guest at Wedding

Ari Rubin as Guest at Wedding

John Steciw as Band Leader

Walter Klimchuk as Priest

Peggy Roeder as Cousin

Treva Tegtmeier as Cousin

Oksana Fedunyszyn as Cousin

Lynn Baber as Cousin

Chipper Lowell as Circus Performer

Michaela Morgan as Nurse

Darryl Phinnessee as Circus Performer / Wedding Guest

Marc Antonio Pritchett as Wedding Guest