Anna Faris as Cindy Campbell

Simon Rex as George

Anthony Anderson as Mahalik

Charlie Sheen as Tom

Regina Hall as Brenda Meeks

Leslie Nielsen as President Baxter Harris

Kevin Hart as CJ

Jeremy Piven as Ross Giggins

Pamela Anderson as Becca

Jenny McCarthy-Wahlberg as Kate

Denise Richards as Annie

Elaine Klimaszewski as Elaine

Diane Klimaszewski as Diane

Drew Mikuska as Cody

Jianna Ballard as Sue

George Carlin as Architect

Queen Latifah as Aunt Shaneequa / The Oracle

Eddie Griffin as Orpheus

Camryn Manheim as Trooper Champlin

Marny Eng as Tabitha

Timothy Stack as Carson Ward

Darrell Hammond as Father Muldoon

Dexter Bell as Toilet Guy

Dame Lee as Rapper #1

Doron Bell as Rapper #2

Simon Cowell as Simon Cowell

Fat Joe as Fat Joe

Ajay Naidu as Sayaman

William S. Taylor as Mr. Meeks

Patricia Idlette as Mrs. Meeks

David Edwards as Ralph

Frank C. Turner as Mr. Meek's Brother

Monica Dillon as Brenda's Grandmother

Lori Stewart as Tabitha's Mother

Jim Bremner as Guy in Chair

Phil Dornfeld as Tabitha's Voice (voice)

Edward Moss as MJ

Dee Jay Jackson as Zubie

D.L. Hughley as John Wilson

Ja Rule as Agent Thompson

Macy Gray as Macy Gray

Redman as Redman

Method Man as Method Man

Raekwon as Raekwon

RZA as RZA

U-God as U-God

Troy Yorke as Alien #1

Marco Soriano as Alien #2

Cliff Solomon as Native American #1

Byron Chief-Moon as Native American #2

Dolly Madsen as Native American #3

John Hainsworth as Tracheotomy Man

Beverley Breuer as Tracheotomy Wife

Jessie Young as Girl Scout

Deanne Henry as Tammy Fae Baker

Eric Breker as Secret Serviceman Jones

Naomi Lawson-Baird as Sweet Tabitha

Abigail Adams as Wedding Guest

Master P as P Masters

Debbie Lee Carrington as Mini Tabitha (uncredited)