Anna Faris as Cindy Campbell

Regina Hall as Brenda Meeks

Craig Bierko as Tom Ryan

Bill Pullman as Henry Hale

Anthony Anderson as Mahalik

Leslie Nielsen as President Baxter Harris

Molly Shannon as Marilyn

Michael Madsen as Oliver

Chris Elliott as Ezekiel

Carmen Electra as Holly

Shaquille O'Neal as Shaq

Phil McGraw as Dr. Phil

Cloris Leachman as Mrs. Norris

Conchita Campbell as Rachel

Beau Mirchoff as Robbie Ryan

Kevin Hart as CJ

DeRay Davis as Marvin

Simon Rex as George

YoungBloodZ as YoungBloodZ

Bryan Callen as Harper

Alonzo Bodden as Jamison

Dave Attell as Knifeman

Holly Madison as Blonde #1

Bridget Marquardt as Blonde #2

Kendra Wilkinson as Blonde #3

Drew Mikuska as Cody

Chingy as Chingy

Fabolous as Gunman

Lil Jon as Gloating Driver

Henry Mah as Mr. Koji

Garrett Masuda as Japanese Ghost Boy

John Reardon as Jeremiah

Campbell Lane as Amos

Catherine Barroll as Female Elder #1

Anna Ferguson as Female Elder #2

Sean Allan as Male Elder #2

Ralph Alderman as Male Elder #3

Brad Sihvon as 'His Brother, The Sheriff!'

Dave Leach as Mordecai

Andrew McNee as Hoss

Tomoko Sato as Japanese Ghost Woman

Edward Moss as Michael Jackson

Dru Williams as Cindy's Husband

Debra Wilson as Oprah

Laura Dash as Saw Villain - Alien

David Mylrea as Zoltar / 'I'll Pay You'

Craig Mazin as Saw Villain (voice)

David Zucker as Zoltar (voice)

Michael McDonald as Tiffany Stone

Champagne Powell as Don King

Steve Archer as Secret Service Agent

Tim Henry as Dock Foreman

Alex Bruhanski as Tiffany's Trainer

Doug Abrahams as Fight Referee

Blaine Anderson as Vendor at Fight

Dale Wolfe as Hang Gliding Man

Ann Warn Pegg as 'Were You Naked?'

Jess McLeod as Little Girl

David MacKay as 'Alien Attack!'

Tony Ali as Terrorist

Jana Mitsoula as Running Woman #1

Sharon Simms as Running Woman #2

Mark Burgess as 'My Bowels Have Stopped Moving!'

Wes Taylor as Marilyn's New Husband

Gwenda Lorenzetti as Mr. Koji's Assistant

Brenda McDonald as Old Lady Henderson

Tim O'Halloran as Pigface Joe

Darren Rizzolo as Spit Take Kid #1

Adam Cannel as Spit Take Kid #2

Sadie Decoste as Spit Take Kid #3

Michelle Grigor as Spit Take Kid #4

Leandro Iddrisu as Spit Take Kid #5

Justin Callan as Spit Take Kid #6

Yan-Kay Crystal Lowe as Chingy's Girl #1

Christie Laing as Chingy's Girl #2

Angelique Naude as Chingy's Really Hot Waitress

Dexter Bell as Chingy's Hype Man

Beverley Breuer as Blonde Woman in Alien Basket

Scott Barratt as Fight Announcer

Barry W. Levy as National Spokesman

Darryl Scheelar as Shotgun Man

Rorelee Tio as Yoko

Steve Kiziak as Tom's Neighbor #1

Link Baker as Tom's Neighbor #2

Kimberley Buchanan as Tom's Neighbor #3

Kathryn Dobbs as School Teacher

Tony Morelli as Ball Scratcher

Tina Hosford as Wet T-Shirt Girl #1

Elisa King as Wet T-Shirt Girl #2

Andrea Morrow as Wet T-Shirt Girl #3

Monica Dillon as Mahalik's Grandmother

Sarah Edmondson as Bar Waitress

Kwesi Ameyaw as Soldier

Ted Friend as Reporter

Daniel Bruce as Belgian Minister

Chic Gibson as UN Diplomat #1

Robbie Segulam as UN Diplomat #2

Nimet Kanji as UN Diplomat #3

Gabriela Cerecero as UN Diplomat #4

Michael Ikeda as UN Diplomat #5

Mina E. Mina as UN Diplomat #6

Ahmad Sharmrou as UN Diplomat #7

Steadwick D'Penha as UN Diplomat #8

Gregory Bennett as Russian Diplomat

Uget Ebony as UN Diplomat #10

George Grove as Doctor

Charlie Sheen as Tom Logan (uncredited)

James Earl Jones as Narrator (uncredited)

Patrice O'Neal as Rasheed (uncredited)

Chris Williams as Marcus (uncredited)

Mashiah Vaughn-Hulbert as Principal (uncredited)

Kimani Ray Smith as Cut Man (uncredited)

Yaroslav Poverlo as Belgian Representative in UN (uncredited)

Amber Borycki as Dancer (uncredited)