Tom Holland as Peter Parker / Spider-Man

Michael Keaton as Adrian Toomes / Vulture

Robert Downey Jr. as Tony Stark / Iron Man

Marisa Tomei as May Parker

Jon Favreau as Happy Hogan

Gwyneth Paltrow as Pepper Potts

Zendaya as Michelle

Donald Glover as Aaron Davis

Jacob Batalon as Ned

Laura Harrier as Liz

Tony Revolori as Flash

Bokeem Woodbine as Herman Schultz / Shocker #2

Tyne Daly as Anne Marie Hoag

Abraham Attah as Abraham

Hannibal Buress as Coach Wilson

Kenneth Choi as Principal Morita

Selenis Leyva as Ms. Warren

Angourie Rice as Betty

Martin Starr as Mr. Harrington

Garcelle Beauvais as Doris Toomes

Michael Chernus as Phineas Mason / Tinkerer

Michael Mando as Mac Gargan

Logan Marshall-Green as Jackson Brice / Shocker #1

Jennifer Connelly as Karen / Suit Lady (voice)

Gary Weeks as Agent Foster

Christopher Berry as Randy

Jorge Lendeborg Jr. as Jason

Tunde Adebimpe as Mr. Cobbwell

Tiffany Espensen as Cindy

Isabella Amara as Sally

Michael Barbieri as Charles

Josie Totah as Seymour

Hemky Madera as Mr. Delmar

Zach Cherry as Street Vendor

Kirk R. Thatcher as Punk on Street

Yu Lew as Car Jacker

Sondra James as Yelling Woman

Bob Adrian as Yelling Man

Gary Richardson as Day Sleeper

Stan Lee as Gary

Joe Hang as Thai Waiter

Wayne Pére as History Teacher

Chris Evans as Steve Rogers / Captain America

Alexa Laraki as Tent Kid

Liza Fagin as Tent Kid

Kerry Condon as Friday (voice)

John Penick as Mr. Hapgood

Ethan Dizon as Tiny

Amy Hill as Decathlon Moderator

Miles Mussenden as Park Ranger

Martha Kelly as Tour Guide

Kevin LaRosa Jr. as Helicopter Pilot

Ren Colley as Ferry Kid

Jennifer Kim as Ferry Mom

Ari Groover as Ferry Commuter

Louis Gonzalez as Ferry Commuter

Stewart Steinberg as Ferry Commuter

Andy Powers as Ferry Commuter

Omar Capra as Yeah Spider-Man Guy

Nitin Nohria as Dean Crimson

Vince Foster as Stark Tower Technician

Brian Schaeffer as Stark Tower Employee

Chris Adams as NYC Pedestrian (uncredited)

Maiya Boyd as Indian Flower Girl (uncredited)

Rebeca Donovan as Drama Club Member (uncredited)

Elli as Rabbi on Subway (uncredited)

Nickolas Wolf as Mascot (uncredited)

Jaine Ye as Chemistry Student (uncredited)

Gina Cordan as DC Tourist (uncredited)

Friday Chamberlain as Skateboarder (uncredited)

Dante Brattelli as Homecoming Dance Student (uncredited)

Melissa Kay Glaze as New Yorker (uncredited)

Donald K. Overstreet as Avenger's Staff Agent (uncredited)

Hallie Ricardo as DC News Reporter (uncredited)

Doug Scroggins III as Stark VTOL Pilot (uncredited)

Marmee Regine Cosico as NY Pedestrian (uncredited)

Harrison Osterfield as Midtown High Student (uncredited)

Chris Silcox as Helicopter D.C. Metro Sniper (uncredited)

Clam Sepulveda as Ned Leed's Dad (uncredited)

Wesley Kuykendoll as Vulture Weapons Tech (uncredited)

Cassidy Alexandra Kahler as Flash's Prom Date (uncredited)

Josh Turner as Inmate (uncredited)

Manuel LAMBERT as Miles Morales