Ryan Reynolds as Guy

Jodie Comer as Millie Rusk / Molotovgirl

Joe Keery as Walter 'Keys' McKeys

Lil Rel Howery as Buddy

Utkarsh Ambudkar as Mouser

Taika Waititi as Antwan Hovachelik

Channing Tatum as Revenjamin Buttons

Aaron W Reed as Dude

Britne Oldford as Barista

Camille Kostek as Bombshell

Mark Lainer as Hostage

Mike Devine as Officer Johnny

Sophie Levy as Big City Dreamer

Vernon Scott as Bank Manager

Naheem Garcia as Convenience Store Owner Joe

Anabel Graetz as Cat Lady Phyllis

Ric Plamenco as Ice Cream Vendor

Kenneth Israel as Businessman

Michael Malvesti as Newsstand Vendor

Colin Allen as Shoe Store Clerk

Michael Tow as Rain Man

Hugh Jackman as Masked Player in Alley (voice)

Dwayne Johnson as Bank Robber #2 (voice)

Tina Fey as Vacuuming Mom (voice)

John Krasinski as Silhouetted Gamer (voice)

Chris Evans as Chris Evans

Alex Trebek as Alex Trebek

Lara Spencer as Lara Spencer

Matthew Cardarople as Keith, the 22-Year-Old Gamer

Jonathan De Azevedo as Jonathan

Destiny Claymore as Art Nerd

Ninja as Ninja

Imane Anys as Pokimane

Lannan Eacott as Lazarbeam

Seán McLoughlin as Jacksepticeye

Daniel Middleton as DanTDM

Charlotte Levy as Tween Gamer Girl

Colette Levy as Foul-Mouthed Little Sister

Mariama Conde as Teenage Girl

Olivia Z. Cote as Teenage Girl

Ryan Doyle as Teenage Boy

Bob Gilliam as Free City News Anchor

Terri Schwartz as IGN Reporter

Eugene Nomura as Japanese Reporter

Euri Nomura as Hinata

Octavia Chavez-Richmond as Real World Coffee Shop Server

Raj Jawa as Quad-Screen Gamer

Charlie Lehmer as Quad-Screen Gamer

Elainy Mata as Quad-Screen Gamer

Jack McLaglen as Quad-Screen Gamer

Jose Guns Alves as Soonami Security Guard

Minh-Anh Day as Soonami Employee

Ella Faria as Austrian Female Gamer

Francisco Marquez as Bank Robber #1

Owen Burke as Bank Robber #2

Timothy John Smith as Bank Robber #3

Justin Johnston as Bank Robber #4

Patrick Vincent Curran as Masked Player in Alley

Lily Steven as 20-Year-Old Female Gamer

Gabrielle Lorthe as 20-Year-Old Female Gamer

Briana Mitchell as 20-Year-Old Female Gamer

Rosario Corso as Silhouetted Gamer

Regina Taufen as Vacuuming Mom

Liam Campos as Kid Gamer

Piper Acord as Contestant

Brett Schneider as Contestant

Omar Ghonim as Carjacking Victim (uncredited)

Tait Fletcher as Viking Warrior (uncredited)

Janelle Feigley as Jogger (uncredited)

Brandon Scales as Businessman (uncredited)