Jim Belushi as Homer Lanza

Whoopi Goldberg as Eddie Cervi

John Waters as Robber #1

Robert Glaudini as Robber #2

James Thiel as Twin #1

Jeff Thiel as Twin #2 (as Jeffrey Thiel)

Andy Jarrell as Trucker

Anne Ramsey as Edna

Jim Mapp as Harmonica Player

Michelle Milantoni as Fat Woman in Pizza Joint

Mickey Jones as Man at Pizza Joint

Annie O'Donnell as Wife at Pizza Joint

Katherine Barrese as Waitress

Tad Horino as Mickey

Karen Black as Belle

Jack Goode Jr. as Tawdry Man

Ernestine McClendon as Esther

Pruitt Taylor Vince as Cashier

Wayne Grace as Preacher

Smitty Smith as Man Shoveling Snow

Lee Armstrong as Husband at Fruit Stand

Jan Bina as Wife at Fruit Stand

Harry Caesar as Street Person

Al Noble as Street Crazy #1

Louis B. Scott Sr. as Street Crazy #2

Sebastian Massa as Bartender

Tommy Lister Jr. as Man in Bar with Gun

Mae Mercer as Ellen

Pat Ast as Maggie Sinclair

Nick LaTour as Bar Customer

Beah Richards as Linda Cervi

Boris Aplon as Driver in Fancy Car

Angelyne as Blonde

Tony Epper as Gas Station Attendant

Vincent Schiavelli as Priest

Jimmie F. Skaggs as Jesus #1

Nancy Parsons as Maid

Tracey Walter as Tommy Dearly

Fritz Feld as Mortician

Barbara Pilavin as Mrs. Lanza

Angelo Bertolini as Mr. Lanza

Sasha Barrese as 4-Year-Old Girl

Don Hanmer as Cashier #2

Ed DeFusco as Bobby French

Yelena Koreneva as

Mark Winn as Homeless man (uncredited)