Audrey Wasilewski as Chef Sue / Librarian (voice)

Frank Welker as Scooby-Doo / Fred Jones (voice)

Giada De Laurentiis as Giada De Laurentiis (voice)

Salli Saffioti as Reporter / Nancy Metcalf (voice)

Matthew Lillard as Shaggy Rogers (voice)

Grey DeLisle as Daphne Blake (voice)

Kate Micucci as Velma Dinkley (voice)

Bobby Flay as Bobby Flay (voice)

Jason Spisak as Bradley Bass (voice)

Dana Snyder as Skip Taylor (voice)

Marcus Samuelsson as Marcus Samuelsson (voice)

Jim Cummings as Jeremiah Noseworthy (voice)