Keanu Reeves as John Constantine

Rachel Weisz as Angela Dodson / Isabel Dodson

Shia LaBeouf as Chas Kramer

Djimon Hounsou as Midnite

Max Baker as Beeman

Pruitt Taylor Vince as Father Hennessy

Gavin Rossdale as Balthazar

Tilda Swinton as Gabriel

Peter Stormare as Lucifer

Jesse Ramirez as Scavenger

José Zúñiga as Detective Weiss

April Grace as Dr. Leslie Archer

Larry Cedar as Vermin Man

Francis Guinan as Father Garret

Suzanne Whang as Mother

Jhoanna Trias as Possessed Girl

Alice Lo as Old Woman

Nicholas Downs as Church Attendant

Tanoai Reed as Midnite Bouncer

Quinn Buniel as 10 Year-Old Constantine

Ann Ryerson as Old Woman on Bus

Stephanie Fabian as Molly's Server

Connor Dylan Wryn as Teenage Constantine

Laz Alonso as Morgue Security Guard

Jeremy Ray Valdez as Liquor Store Clerk Nico

Jose Molina as Scavenger #2

Barbara Pilavin as Old Woman on Bus (Demon)

C.W. Pyun as Korean Man

Sharon Omi as Female Tenant

Edward J. Rosen as Liquor Store Clerk

John Gipson as Smoking Man

Roberto Kawata as Police Officer

Michelle Monaghan as Ellie (uncredited)

R.A. Rondell as Man in Jeep (uncredited)

Chad Stahelski as Demon in Hospital (uncredited)

Kevin Alejandro as Border Patrol (uncredited)