Randy Quaid as Eddie Johnson

Miriam Flynn as Catherine Johnson

Dana Barron as Audrey Griswold

Jake Thomas as Third Johnson

Sung-Hi Lee as Muka Laka Miki

Julian Stone as Melbourne Jack

Beverly Garland as Aunt Jessica

Stephen Furst as Hospital Doctor

Rodger Bumpass as Lab Visitor / Plumber (voice) / Air Controller (voice)

Eric Idle as English Victim

Fred Willard as Professor Doornitz

Ed Asner as Uncle Nick

Kate Simmons as Paige

Maya Quin as Airplane Hostess

Angela Bennett as Doornitz's Assistant

Sal Catalano as Taxi Driver

Jay Greenberg as Santa Claus Security Guard

Trish Suhr as Woman (Next to Nick on Plane)

Cassidy Laikin as Girl in Airport

Caroline Walker as Controller's Wife

Bill Power as Air Traffic Controller