Rajinikanth as 'Annaatthe' Kaalaiyaan

Keerthy Suresh as Thanga Meenakshi

Jagapati Babu as Udhav Palekar

Soori as Pachakili

Nayanthara as Pattamal

Meena as Mangayarkarasi

Khushboo as Angayarkanni

Bala as Arjun

Prakash Raj as Nattadurai

Abhimanyu Singh as Manoj Palekar

Vela Ramamoorthy as Kaalaiyan’s uncle

Pandiarajan as Angayarkanni’s husband

Livingston as Mangayarkarasi’s husband

Sathyan Sivakumar as Mangayarkarasi’s brother

Sathish as Angayarkanni’s brother

George Mariyan as Komberi Mookan

Redin Kingsley as Nattadurai's Brother In Law

Hrishikesh as A Potential Groom

Thavasi as Priest

Kabali Vishwanth as

Arjai as

Nadodigal Gopal as Kaalaiyan's Uncle

Kulappulli Leela as Kaalaiyaan’s grandmother

Billy Murali as Manoj Palekar's Henchman

Brana as