Charles Fleischer as Roger Rabbit (voice)

April Winchell as Young Baby Herman / Mrs. Herman (voice)

Lou Hirsch as Adult Baby Herman (voice)

Corey Burton as Orderly (voice)

Kathleen Turner as Jessica Rabbit (voice)

Sol Pavlovsky as Raoul J. Raoul

William Bronder as Sign Carrier

Charles Noland as Sign Carrier

Richard Williams as Droopy Dog (voice)

June Foray as Nurse (voice) (uncredited)