Charles Fleischer as Roger Rabbit (voice)

Kathleen Turner as Jessica Rabbit (voice)

April Winchell as Young Baby Herman / Mrs. Herman (voice)

Lou Hirsch as Adult Baby Herman (voice)

Corey Burton as Droopy Dog (voice)

Frank Welker as Bull (voice)

Damian London as Fritz

Joni Barnes as Secretary

Jimmy Bracken as Cameraman

Angel Cook as Fireman