Mike Birbiglia as Matt

Lauren Ambrose as Abby

James Rebhorn as Frank

Carol Kane as Linda

Cristin Milioti as Janet

Aya Cash as Hannah

Marylouise Burke as Aunt Lucille

Loudon Wainwright III as Uncle Max

Ben Levin as Philip

Henry Phillips as Henry

Jessi Klein as Lynn

Emily Meade as Samantha

Danny Borbon as Tommy

Amanda Perez as Tammy

Lucy DeVito as Hilary

Kristen Schaal as Cynthia

Alex Karpovsky as Ian

Ron Nakahara as Ron

Wyatt Cenac as Chris

Ira Glass as Wedding Photographer

Marc Maron as Marc

David Wain as Pete

Teddy Cañez as Pedro

William C. Dement as Dr. Dement

Raymond Anthony Thomas as Dr. Regan

Amy Schumer as Amy

Sondra James as Colleen

Alberto Bonilla as Wedding Planner

John Lutz as Chip

Philip Ettinger as Doug

Jason Selvig as Dave

Azhar Khan as Tow Truck Driver

Angelic Zambrana as Melissa

Meena Nerurkar as Realtor

Edward James Hyland as General

Chike Johnson as Lieutentant

Alan Wilkis as Guitar Strumming Emcee

James Creque as Interviewer

Santos Morales as Large Adult Man

James Fauvell as Towel Guy In Elevator

Chavez Ravine as Cleaning Lady

Kevin Barnett as Union Hall Comic

Chris Cantwell as Overzealous Student