Charlton Heston as Sherlock Holmes

Richard Johnson as Dr. Watson

Susannah Harker as Irene St. Claire

Edward Fox as Alistair Ross

John Castle as Neville St. Claire

Simon Callow as Inspector Lestrade

Clive Wood as Jonathan Small

Kiran Shah as Tonga

Lloyd McGuire as P.C. Hopkins

Stefan Kalipha as Wali Dad

Kaleem Janjua as Durga Dass

James Coyle as Birdy Johnson

Sidney Livingstone as Mordecai Smith

Roly Lamas as Leper