Johnny Depp as George Jung

Penélope Cruz as Mirtha Jung

Franka Potente as Barbara Buckley

Rachel Griffiths as Ermine Jung

Ray Liotta as Fred Jung

Jordi Mollà as Diego Delgado

Cliff Curtis as Pablo Escobar

Paul Reubens as Derek Foreal

Miguel Sandoval as Augusto Oliveras

Max Perlich as Kevin Dulli

Ethan Suplee as Tuna

Kevin Gage as Leon Minghella

Tony Amendola as Sanchez

Jesse James as Young George

Emma Roberts as Young Kristina Jung

Dan Ferro as Cesar Toban

Bobcat Goldthwait as Mr. T

Miguel Pérez as Alessandro

Michael Tucci as Dr. Bay

Monet Mazur as Maria

Lola Glaudini as Rada

Jennifer Gimenez as Inez

Jaime King as Kristina Jung

Charles Noland as Jack Stevens

Pamela Abdy as Beach Woman #3

John Harrington Bland as FBI Waiter #1

Jimmy Burke as FBI Waiter #4

Brantley Bush as FBI Waiter #3

Kevin Chapman as DEA Eastham

Ted Demme as Archie Sigmond

Daniel Escobar as Emilio Ochoa

Tracy Falco as Beach Woman #2

Vanessa Grayson as Stewardess #3

Elif Guertin as Stewardess #2

Faith Hoover as Stewardess #6

Kristina Jung as Clerk

Dorothy Lyman as Judge (Chicago)

Genevieve Maylam as Beach Woman #1

Kathleen Mullan as Beach Woman #5

Meriah Nelson as Stewardess #4

Sophie Tsimel as Beach Woman #4

The Dawk as Guard (Visit Area #2)

Crystal Erickson as Stewardess #1

Jean-Carlos Felix as Prison Guard (Warden's Office)

Lazaro Galarraga as Band Singer

Brian Goodman as Guard Gus

Josh Herman as Detective #1

Brad Hunt as GG

Patrick Husted as Bank Manager (Mass.)

Ralph Kampshoff as Guard (Visit Area ä1)

Ajgie Kirkland as James Trout

Skip O'Brien as Customs Agent

Richard LaGravenese as Detective #2

Roberto Lopez as Guard (Danbury)

Lydell M. Cheshier as Inmate #3

Jodie Mann as Nurse (Cape Cod)

Charles Martiniz as Bank Employee

Gonzalo Menendez as Ramon Ochoa

Mauricio Mendoza as Benny

Carlos Mendoza as Tony

Alan James Morgan as Young Tuna

Randy Mulkey as Employee #1

Tony Perez as Bank President

Jack Polick as Ben

Michael Ralph as Inmate #2

Raoul N. Rizik as Rafael Ojeda

Matt Robinson as Inmate #1

Elizabeth Rodriguez as Martha Oliveras

Bert Rosario as Bank President (Panama)

Leslie Schirrmacher as Stewardess #5

Dale Snowberger as FBI Waiter #2

Julia Vera as Clara Blanca

Santiago Verdu as Juan Carlos

Pamela Walker as FBI Waiter #5

Twyla Banks as Inmate's Daughter (uncredited)

Greg Bronson as Prison Inmate (uncredited)

Nick Cassavetes as Man in Derek's Salon (uncredited)

Janine Foster as Flight Attendant (uncredited)

Jo Price as Business Woman (uncredited)

Anna de Cardi as Friend at Pool Party (uncredited)