Denzel Washington as Jake Shuttlesworth

Ray Allen as Jesus Shuttlesworth

Rosario Dawson as Lala Bonilla

Milla Jovovich as Dakota Burns

Hill Harper as Coleman "Booger" Sykes

Ned Beatty as Warden Wyatt

Jim Brown as Spivey

Joseph Lyle Taylor as Crudup

Bill Nunn as Uncle Bubba

Michele Shay as Aunt Sally

John Turturro as Billy Sunday

Shaquille O'Neal as Shaquille O'Neal

Charles Barkley as Charles Barkley

Michael Jordan as Michael Jordan

Jill Kelly as Suzie

Chasey Lain as Buffy

Robin Roberts as Robin Roberts

Scottie Pippen as Scottie Pippen

Reggie Miller as Reggie Miller

Bill Walton as Bill Walton

Dick Vitale as Dick Vitale

Bobby Cremins as Bobby Cremins

Rick Pitino as Rick Pitino

Jim Boeheim as Jim Boeheim

George Karl as George Karl

Clem Haskins as Clem Haskins

Denny Crum as Denny Crum

Nolan Richardson as Nolan Richardson

Roy Williams as Roy Williams

John Chaney as John Chaney

John Thompson as John Thompson

Lute Olson as Lute Olson

Dean Smith as Dean Smith

Jennifer Esposito as Ms. Janus

Zelda Harris as Mary Shuttlesworth

Lonette McKee as Martha Shuttlesworth

Thomas Jefferson Byrd as Sweetness

Roger Guenveur Smith as Big Time Willie

Rick Fox as Chick Deagan

Leonard Roberts as D'Andre Mackey

Arthur J. Nascarella as Coach Cincotta

Ron Cephas Jones as Prison Guard Burwell

Al Palagonia as Dom Pagnotti

Heather Hunter as Female In Sex Montage

Kim Director as Lynn

Ava Lee Scott as Young Girl

Travis Best as Sip

Walter McCarty as Mance

John Wallace as Lonnie

Saul Stein as Prison Guard Brooks

Jade Yorker as Jesus Shuttlesworth - Age 12

Shortee Red as Booger - Age 12

Quinn Harris as Mary Shuttlesworth - Age 6

Tom Davis as Tom Davis

Gus Johnson as PSAL Announcer

Stuart Scott as TV Announcer

Ray Clay as Tech U Announcer

J.C. MacKenzie as Doctor Cone

Coati Mundi as Clerk in Motel

Avery Glymph as Sneaker Clerk

Ciara A. Shields as Mary's Friend

Lin Que Ayoung as 'I Love You' Leech

Angela Meryl as 'I Love You' Leech

Dionne Phillips as 'I Love You' Leech

Gary Frith as 'I Love You' Leech

Jamie Hector as 'I Love You' Leech

Harry Philippe as 'I Love You' Leech

Kelli-Lin McMillan as 'I Love You' Leech

Lamar Tookes as 'I Love You' Leech

Mark Breland as Man with Gat

Christopher Wynkoop as The John

Alonzo Scales as Goose

Lori Rom as June

Felicia Finley as Molly

Anthony T. Paige as Correctional Officer (as Tony Paige)