Ben Stiller as Larry Daley

Carla Gugino as Rebecca

Dick Van Dyke as Cecil

Mickey Rooney as Gus

Bill Cobbs as Reginald

Jake Cherry as Nick Daley

Ricky Gervais as Dr. McPhee

Robin Williams as Theodore Roosevelt

Kim Raver as Erica Daley

Patrick Gallagher as Attila the Hun

Rami Malek as Ahkmenrah

Pierfrancesco Favino as Christopher Columbus

Charlie Murphy as Taxi Driver

Steve Coogan as Octavius

Mizuo Peck as Sacajawea

Kerry van der Griend as Neanderthal #1

Dan Rizzuto as Neanderthal #2

Matthew Harrison as Neanderthal #3

Jody Racicot as Neanderthal #4

Paul Rudd as Don

Anne Meara as Debbie

Martin Christopher as Lewis

Martin Sims as Clark

Randy Lee as Hun #1

Darryl Quon as Hun #2

Gerald Wong as Hun #3

Paul Cheng as Hun #4

Teagle F. Bougere as Teacher (Mike)

Pat Kiernan as TV News Anchor

Nico McEown as Friend #1

Meshach Peters as Friend #2

Matthew Walker as Politician

Jason McKinnon as Irish Worker

Jono Lee as Chinese Rail Worker

Jason Vaisvila as Viking

Cade Wagar as Viking

Cory Martin as Chinese Terra Cota Soldier

Brad Garrett as Easter Island Head (voice)

Crystal the Monkey as Dexter

Che Landon as Pretty Tourist Girl (uncredited)

Phil Proctor as Moose (uncredited)

Gary Sievers as Viking Warrior (uncredited)

Owen Wilson as Jedediah Smith (uncredited)