Susan Sarandon as Lou

Bette Midler as Marilyn

Megan Mullally as Alice

Sheryl Lee Ralph as Kitty

Timothy V. Murphy as Captain Ernie

Bruce Greenwood as Ted

Kadan Well Bennett as Nathan

Renika Williams as Shivani

Abigail Dolan as Sheila

David Goren as Brandon

Brandee Evans as Leslie

Michael Bolton as Michael Bolton

Sophie von Haselberg as Amanda

Déjá Dee as Dr. Rhonda Brown

Kaden Taylor as Bobby

Avangeline Friedlander as Aimee

Molly Hargrave as Young Bridal Assistant

Nicholas Velez as Joaquin

Micah Engle as Bartender

Lex Lauletta as Cute Guy

John Crosby as Officiant

Thao Le as Nurse

Mike Bevins as Airline Passenger (uncredited)

Mitchell Patrick Greene as Wedding Caterer (uncredited)

Pamela Hardy as Wedding Planner (uncredited)

Angela Lentz as Airline Stewardess (uncredited)

Art Newkirk as Soiree Attendee (uncredited)

Ally Shawver as Server (uncredited)

Tamara Starnes as Party Goer (uncredited)

Zachary Vazquez as Handsome Champagne Waiter (uncredited)

Joseph D. Webb as Restaurant Patron (uncredited)