Assumpta Serna as Juana Inés de la Cruz

Dominique Sanda as La Virreina

Héctor Alterio as El Virrey

Lautaro Murúa as Arzobispo

Alberto Segado as Padre Miranda

Franklin Caicedo as Santa Cruz

Graciela Araujo as Hermana Ursula

Hugo Soto as Amante en flashback del palacio

Márgara Alonso as

Lidia Catalano as Madre de Juana

Margarita Padín as

Gerardo Romano as Sigüenza

Cecilia Roth as La Virreina (voice)

Alejandra Colunga as

Rosario Bléfari as

Felisa Rocha as

Ema Rivera as

Fernando Noy as

José Martin as

Walter Soubrié as

Jesús Berenguer as

Guillermo Marín as

Nicolás Alvarado as

Susana Cortínez as

Alice Elias as

Mónica Lacoste as

Pedro Caña as

Marcos Woinsky as Miembro auditoria de textos de Juana

Isaac Haimovici as

Néstor Zacco as

Arnaldo Colombarolli as

Alejandro Maci as

Oscar Carmelo Milazzo as Bufón palacio

Nicolas Cardasco as

Jean Pierre Reguerraz as

Lorena López as

Eliana Ronsisvalli as

Fernanda Ronsisvalli as

Andrea Rodriguez as

Karina Allegue as

Luciana Mastromaura as

Victoria Solarz as

Cristina Scaramuzza as

Norma Suzat as