Zooey Deschanel as Happy

John Goodman as Happy's Father

Paul Dano as Brian

Ed Asner as Kirby Weathersby

Jane Alexander as Barbara Weathersby

Ian Roberts as John Weathersby

Robert Stanton as James Weathersby

Clarke Peters as Roger Stovall

Daniel Stewart Sherman as Kevin Blue

Mary Page Keller as Marguerite Lolly

Zach Galifianakis as Homeless Man

Brian Avers as Larry Arbogast

Leven Rambin as Missy Thaxton

Susan Misner as Melanie Lolly

Matt Walton as Conner Williams

Ilana Levine as Ducky Saltinstall

Louis Ozawa as Matsubara

Kenji as Kanagae

Tatsuo Ichikawa as Nagata

Sean Dugan as Gary Wynkoop

Frank Harts as Kenyatta Folds

Rob Munk as Dr. Sarazine

Sharon Wilkins as Linda

Pierre Epstein as Jacques

Sara Lamm as Natasha Klukowski

Tara Greenway as Lucy (Mattress Customer)

Zachary Knower as Ted (Mattress Customer)

Mylinda Hull as Woman (Mattress Customer)

Jerry Richardson as Man (Mattress Customer)

Will McLaughlin as Receptionist

Adam Nagata as Attendant

Aryn Elaine Cole as John's Masseuse

Nicolas Cruz as Octavio

Nekia Daste as Make Up Artist

Gina Gabrielli as Eastern European Masseuse

Cassidy Gard as Girl in Couple

RJ Konner as Commuter

Anna Kuchma as Eastern European Masseuse