Milla Jovovich as Alice

Sienna Guillory as Jill Valentine

Oded Fehr as Carlos Olivera

Thomas Kretschmann as Major Cain

Sophie Vavasseur as Angela "Angie" Ashford

Razaaq Adoti as Sgt. Peyton Wells

Jared Harris as Dr. Ashford

Mike Epps as L.J.

Sandrine Holt as Terri Morales

Matthew G. Taylor as Nemesis

Zack Ward as Sergente Nicholai Ginovaeff

Iain Glen as Dr. Isaacs

Dave Nichols as Captain Henderson

Stefen Hayes as Yuri Loginova

Geoffrey Pounsett as Mackenzie

Shaun Austin-Olsen as Priest

Geny Walters as Mrs. Priest

Megan Fahlenbock as Marla Mapes

Robert Morelli as Director

Aaron Abrams as Assistant

Chris Benson as Lance Halloran

Martin Martinuzzi as Overworked Detective

Brad Borbridge as Overworked Sergeant

Frank Chiesurin as Sniper

Ron Benjamin as Bum

Kevin Hare as Home Owner / Scientist

Heather Dick as Older Woman

Alex Courey as Suit #1

John De Toro as Suit #2

Billy Khoury as Suit #3

Sava Drayton as Suit #4

Nicole Ann St. Hill as Undead Gaudy Hooker

Ricardo Betancourt as Burly Cop #1

Ted Ludzik as Burly Cop #2

Michelle Latimer as Tech #1

Catherine Burdon as Tech #2

Rebecca Sims as Undead Little Girl

Christopher Weedon as Undead Little Boy #1

Billy Parrott as Security Guard

Derek Aasland as Featured Graveyard Undead 1 (as Derek Asland) / Featured "Surplus" Undead #3

Richard Harte as Featured Graveyard Undead 2 / Featured Rooftop Undead #2

Simon Girard as Chopper Pilot #1

Dean Copkov as Chopper Pilot #2

Jeff White as Chopper Pilot #4

Timothy Burd as Refugee #1

Natalie Charles as Refugee #2

Pierre Henry as Screaming Soldier

Jim Codrington as Lieutenant

Deborah Valente as Tech

Malcolm Fiddick as Reflection Undead

Malcolm Xerxes as Featured City Hall Undead #1

Michy Gustavia as Featured City Hall Undead #2

Shane Mackinnon as Featured City Hall Undead #3

Ed Fielding as Featured City Hall Undead #4

Stephen R. Hart as Featured City Hall Undead #5

Sandi Stahlbrand as Reporter #1

Christopher Marren as Guard

Tom Gerhardt as Zombie Dad

Amber Marshall as Daughter

Venice Grant as Undead Stripper #1

Ana Danilina as Undead Stripper #2

Ingrid Johansson as Featured IV Woman Undead

Jeffrey Weedon as Undead Little Boy #2

Melanie Tonello as Featured Undead Kid #1

Annabel Chu as Featured Undead Kid #2

Joe Jefferson as Featured Undead Kid #3

Heather Braaten as Featured Rooftop Undead #1

Joe Silvaggio as Featured Rooftop Undead #3 (as Joey Beck)

Eric Morgan as Featured Undead City Walker #1

Gene Pyrz as Featured Undead City Walker #2

Torquil Colbo as Featured Undead City Walker #3

Joan Moore as Featured Undead City Walker #4

Peter C. Wylde as Featured Undead City Walker #5

Garry Geddes as Featured Undead City Walker #6

Dionne Renee as Featured Undead City Walker #7

Janessa Crimi as Featured Undead Kid #4

Dan Ellery as Featured Graveyard Undead 1

Sharon Moore as Featured "Surplus" Undead #2

Jo Chim as Network Anchor #1

Bobby Prochaska as Network Anchor #2

Jazz Mann as Reporter #2

Larissa Gomes as Reporter #3

Gregory White as Lab Technician

Roman Podhora as Leader Umbrella Guard

Brian King as Umbrella Gate Guard

Rob Hall as Featured School Undead

John Migliore as Zombie (uncredited)

Yaron Betan as Featured Racoon Police (uncredited)

Martin Crewes as Chad Kaplan (uncredited)

Brandon Marc Gagne as Zombie (uncredited)

Ryan McCluskey as M. Grey (uncredited)

Michael C. Newsome as Detective (uncredited)

Avi Salem as Refugee (uncredited)

Alexander Witt as Umbrella Sniper (uncredited)

Paul Puzzella as Zombie (uncredited)