Salli Saffioti as Clawdeen Wolf / Cleo de Nile (voice)

Kate Higgins as Frankie Stein / Airport Announcer / Catrine DeMew (voice)

Erin Fitzgerald as Abbey Bominable / Rochelle Goyle / C.A. Cupid / Spectra (voice)

Cindy Robinson as Madame Ghostier / Jackson Jekyll / Holt Hyde / Operetta (voice)

Debi Derryberry as Draculaura (voice)

Laura Bailey as Lagoona Blue / Bloodgood / Skelita Calaveras (voice)

Stephanie Sheh as Jinafire Long (voice)

Audu Paden as Ghoulia Yelps / Mr. Hackington / Yeti / Sea Monster (voice)

America Young as Howleen Wolf / Toralei Stripe (voice)

Ogie Banks as Clawd Wolf (voice)

Evan Smith as Deuce Gorgon / Garrott DuRoque / Gillington 'Gil' Webber (voice)

Cam Clarke as Heath Burns / Mr. Rotter (voice)

Julie Maddalena as Robecca Steam / Venus McFlytrap (voice)

Garrett Sander as Ghost Cat (voice)

Jonathan Lipow as Tiki People (voice)

Dustin McKenzie as Clawdeen's Design Book (voice)