Kate Higgins as Frankie Stein (voice)

Laura Bailey as Lagoona Blue / Headless Headmistress Bloodgood (voice)

Salli Saffioti as Clawdeen Wolf / Cleo de Nile (voice)

Debi Derryberry as Draculaura (voice)

Evan Smith as Deuce Gorgon / Gillington "Gil" Webber / Ted / Mike (voice)

Keith Silverstein as Bartleby Farnum (voice)

Malcolm Danare as Kipling (voice)

Erin Fitzgerald as Abbey Bominable / Spectra Vondergeist / C.A. Cupid (voice)

Audu Paden as Ghoulia Yelps / Manny Taur / Nightmare / Slo Mo (voice)

George Newbern as Andy Beast (voice)

Jonathan Lipow as The Tikis (voice)

Ogie Banks as Clawd Wolf (voice)

Cam Clarke as Heath Burns / Ghost (voice)

Cindy Robinson as Jackson Jekyll / Holt Hyde / Operetta (voice)

America Young as Howleen Wolf / Toralei / Elephant Girl 1 / Purrsephone (voice)