Jerry Nelson as Emmet Otter / Weasel / Doc Bullfrog / Melissa Rabbit / Yancy Woodchuck (voice)

Frank Oz as Chuck (voice)

Marilyn Sokol as Ma Otter (voice)

Richard Hunt as Charlie / Lizard / George Rabbit (voice)

Eren Ozker as Gretchen Fox / Hetty Muskrat / Mrs. Mink / Old Lady Possum (voice)

Jim Henson as Kermit the Frog / Harrison Fox / Harvey / Snake (voice)

Dave Goelz as Wendell / Pop-eyed Catfish / Will Possum (voice)