Steve Carell as Gru / Dru (voice)

Kristen Wiig as Lucy Wilde (voice)

Trey Parker as Balthazar Bratt (voice)

Miranda Cosgrove as Margo (voice)

Dana Gaier as Edith (voice)

Nhev Scharrel as Agnes (voice)

Pierre Coffin as Mel / Minions / Museum Director / Additional Voice (voice)

Steve Coogan as Fritz / Silas Ramsbottom (voice)

Julie Andrews as Gru’s Mom (voice)

Jenny Slate as Valerie Da Vinci (voice)

Michael Beattie as Scar-Faced Man / TMZ Announcer (voice)

Andy Nyman as Clive the Robot (voice)

Adrian Ciscato as Niko (voice)

Brian T. Delaney as Commercial Announcer / Military Officer / Additional Voice (voice)

Katia Saponenko as Niko’s Mother (voice)

Ken Daurio as Celebrity (voice)

Jude Alpers as Commercial Kid (voice)

Cory Walls as Vincenzo (voice)

Sophie M. Siadatpour as Little Girl (voice)

Lori Alan as Additional Voice (voice)

Carlos Alazraqui as Additional Voice (voice)

Kyle Balda as Additional Voice (voice)

Bob Bergen as Additional Voice (voice)

John Cygan as Additional Voice (voice)

Bill Farmer as Additional Voice (voice)

Danny Mann as Additional Voice (voice)

Stephanie De Meautis as Additional Voice (voice)

Bruno Dequier as Additional Voice (voice)

Teresa Ganzel as Additional Voice (voice)

Jess Harnell as Additional Voice (voice)

John Kassir as Additional Voice (voice)

Mona Marshall as Additional Voice (voice)

Laraine Newman as Additional Voice (voice)

Jan Rabson as Additional Voice (voice)

Mindy Sterling as Additional Voice (voice)

Tara Strong as Additional Voice (voice)

Jim Ward as Additional Voice (voice)

Gregg Berger as Additional Voice (voice)

Chris Renaud as Additional Minions (voice) (uncredited)

Matthew Wood as Additional Voice (voice) (uncredited)

Gad Elmaleh as (voice) (uncredited)

Arié Elmaleh as (voice) (uncredited)

Audrey Lamy as (voice) (uncredited)

David Marsais as (voice) (uncredited)