Steve Carell as Gru / Dru (voice)

Kristen Wiig as Lucy Wilde (voice)

Trey Parker as Balthazar Bratt (voice)

Miranda Cosgrove as Margo (voice)

Dana Gaier as Edith (voice)

Nhev Scharrel as Agnes (voice)

Pierre Coffin as Mel / Minions / Museum Director / Additional Voices (voice)

Steve Coogan as Fritz / Silas Ramsbottom (voice)

Julie Andrews as Gru’s Mom (voice)

Jenny Slate as Valerie Da Vinci (voice)

Michael Beattie as Scar-Faced Man / TMZ Announcer (voice)

Andy Nyman as Clive the Robot (voice)

Adrian Ciscato as Niko (voice)

Brian T. Delaney as Commercial Announcer / Military Officer / Additional Voice (voice)

Katia Saponenko as Niko’s Mother (voice)

Ken Daurio as Celebrity (voice)

Jude Alpers as Commercial Kid (voice)

Cory Walls as Vincenzo (voice)

Sophie M. Siadatpour as Little Girl (voice)

Lori Alan as Additional Voices (voice)

Carlos Alazraqui as Additional Voices (voice)

Kyle Balda as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Gregg Berger as Additional Voice (voice)

John Cygan as Additional Voice (voice)

Bill Farmer as Additional Voices (voice)

Danny Mann as Additional Voices (voice)

Stephanie De Meautis as Additional Voice (voice)

Bruno Dequier as Additional Voice (voice)

Teresa Ganzel as Additional Voices (voice)

Jess Harnell as Additional Voices (voice)

John Kassir as Additional Voice (voice)

Mona Marshall as Additional Voice (voice)

Laraine Newman as Additional Voice (voice)

Jan Rabson as Additional Voices (voice)

Mindy Sterling as Additional Voice (voice)

Tara Strong as Additional Voices (voice)

Jim Ward as Additional Voice (voice)

Gregg Berger as Additional Voices (voice)

Chris Renaud as Additional Minions (voice) (uncredited)

Matthew Wood as Additional Voice (voice) (uncredited)