Ray Romano as Manny (voice)

John Leguizamo as Sid (voice)

Denis Leary as Diego (voice)

Queen Latifah as Ellie (voice)

Seann William Scott as Crash (voice)

Josh Peck as Eddie (voice)

Simon Pegg as Buck (voice)

Keke Palmer as Peaches (voice)

Jennifer Lopez as Shira (voice)

Neil deGrasse Tyson as Neil deBuck Weasel (voice)

Jesse Tyler Ferguson as Shangri Llama (voice)

Jessie J as Brooke (voice)

Adam Devine as Julian (voice)

Wanda Sykes as Granny (voice)

Melissa Rauch as Francine (voice)

Michael Strahan as Teddy (voice)

Nick Offerman as Gavin (voice)

Max Greenfield as Roger (voice)

Lilly Singh as Bubbles and Misty (voice)

Chris Wedge as Scrat (voice)

Stephanie Beatriz as Gertie (voice)

Robert Cardone as Freaky Bobby (voice)

Byron Thames as Additional Voices (voice)

Rif Hutton as Additional Voices (voice)

Chris Campbell as Additional Voices (voice)

Holly Dorff as Additional Voices (voice)

Moosie Drier as Additional Voices (voice)

Jason Fricchione as Additional Voices (voice)

Jackie Gonneau as Additional Voices (voice)

Hope Levy as Additional Voices (voice)

Terence Mathews as Additional Voices (voice)

Edie Mirman as Additional Voices (voice)

Juan Pope as Additional Voices (voice)

Ruth Zalduondo as Additional Voices (voice)

David Zyler as Additional Voices (voice)

Ashley Peldon as Additional Voices (voice)

Carlos Ponce as Mariachi Beaver (voice)

Randy Thom as Hyrax Minister (voice)