Ray Romano as Manny (voice)

John Leguizamo as Sid (voice)

Denis Leary as Diego (voice)

Seann William Scott as Crash (voice)

Josh Peck as Eddie (voice)

Queen Latifah as Ellie (voice)

Jennifer Lopez as Shira (voice)

Peter Dinklage as Captain Gutt (voice)

Wanda Sykes as Granny (voice)

Keke Palmer as Peaches (voice)

Josh Gad as Louis (voice)

Nick Frost as Flynn (voice)

Aziz Ansari as Squint (voice)

Alain Chabat as Silas (voice)

Kunal Nayyar as Gupta (voice)

Drake as Ethan (voice)

Nicki Minaj as Steffie (voice)

Rebel Wilson as Raz (voice)

Alan Tudyk as Milton / Hunky Siren (voice)

Ester Dean as Female Siren (voice)

Eddie 'Piolin' Sotelo as Uncle Fungus (voice)

Joy Behar as Eunice (voice)

Heather Morris as Katie (voice)

Chris Wedge as Scrat (voice)

Christopher Campbell as Creature Siren (voice)

Karen Disher as Scratte (voice)

Marieve Herington as Additional Voices (voice)

Lucas Leguizamo as Additional Voices (voice)

Allegra Leguizamo as Additional Voices (voice)

Jason Fricchione as Dumb Mammoth / Various (voice)

Ben Gleib as Marshall (voice)

George Jacobs as Beaver (voice)

James Palumbo as Panicked Start (voice)

Simon Pegg as Buck (voice)

Alexandra Romano as Meghan (voice)

Patrick Stewart as Ariscratle (voice)

Brian Scott McFadden as Additional Voices (voice)

Ashley Albert as Additional Voices (voice)

Edita Brychta as Additional Voices (voice)

Dennis T. Carnegie as Additional Voices (voice)

Aimée Castle as Additional Voices (voice)

Jim Conroy as Additional Voices (voice)

Jason Harris as Additional Voices (voice)

Sondra James as Additional Voices (voice)

Alexa Kahn as Additional Voices (voice)

Bill Lobley as Additional Voices (voice)

Chris Phillips as Additional Voices (voice)

Tara Sands as Additional Voices (voice)

Keith Silverstein as Additional Voices (voice)