Ray Romano as Manny (voice)

John Leguizamo as Sid (voice)

Denis Leary as Diego (voice)

Queen Latifah as Ellie (voice)

Seann William Scott as Crash (voice)

Josh Peck as Eddie (voice)

Jay Leno as Fast Tony (voice)

Will Arnett as Lone Gunslinger Vulture (voice)

Chris Wedge as Scrat (voice)

Peter Ackerman as Dung Beetle Dad (voice)

Caitlin Rose Anderson as Glypto Boy Billy / Beaver Girl (voice)

Connor Anderson as Rhino Boy / Beaver Boy (voice)

Joseph Bologna as Mr. Start (voice)

Jack Crocicchia as Elk Boy (voice)

Peter DeSève as Condor Chick (voice)

Ariel Winter as Additional Voices (voice)

Clea Lewis as Female Mini Sloth (voice)

Stephen Root as Aardvark Dad (voice)

Nicole DeFelice as Start Girl (voice)

Debi Derryberry as Diatryma Mom (voice)

Marshall Efron as Start Dad (voice)

Tom Fahn as Stu / Male Ox (voice)

Jason Fricchione as Molehog Grandpa / Shovelmouth Male (voice)

George Jacobs as Beaver Dad (voice)

Brian Scott McFadden as Glyptodon (voice)

Jansen Panettiere as Shovelmouth Boy (voice)

Gregory Romano as Start Boy 1 (voice)

Matt Romano as Start Boy 2 (voice)

Carlos Saldanha as Dodo (voice)

Manoela Scarpa Saldanha as Molehog Kid 1 (voice)

Sofia Scarpa Saldanha as Molehog Kid 2 (voice)

Reyna Shaskan as Diego's Bird Girl (voice)

James Sie as Freaky Male (voice)

Cindy Slattery as Aardvark Mom (voice)

Mindy Sterling as Female Ox (voice)

Renée Taylor as Mrs. Start (voice)

Alan Tudyk as Cholly (voice)

Claudia Besso as Additional Voices (voice)

Madeleine Martin as Additional Voices (voice)

Sherry Lynn as Additional Voices (voice)

Mickie McGowan as Additional Voices (voice)

Emily Anderson as Additional Voices (voice)

Jack Angel as Additional Voices (voice)

Shane Baumel as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Kyle J. Bogert as Additional Voices (voice)

Rodger Bumpass as Additional Voices (voice)

Paul Butcher as Additional Voices (voice)

Blanca Camacho as Additional Voices (voice)

John Cygan as Additional Voices (voice)

Jennifer Darling as Additional Voices (voice)

Olivia DeLaurentis as Additional Voices (voice)

Harrison Fahn as Additional Voices (voice)

Bill Farmer as Additional Voices (voice)

Crispin Freeman as Additional Voices (voice)

Tim Kirkpatrick as Additional Voices (voice)

David H. Kramer as Additional Voices (voice)

Danny Mann as Additional Voices (voice)

Laura Marano as Additional Voices (voice)

Matt McCarthy as Additional Voices (voice)

Laraine Newman as Additional Voices (voice)

Jan Rabson as Additional Voices (voice)

Zack Shada as Additional Voices (voice)

Thomas Sharkey as Additional Voices (voice)

Ross Simanteris as Additional Voices (voice)

Rachel Stand as Additional Voices (voice)

Spencer Lacey Ganus as Additional Voices (voice)

Jess Harnell as Additional Voices (voice)

Alex Sullivan as James (voice)

James Godwin as Traffic Vulture