Ed Helms as Rusty Griswold

Christina Applegate as Debbie Griswold

Skyler Gisondo as James Griswold

Steele Stebbins as Kevin Griswold

Chris Hemsworth as Stone Crandall

Leslie Mann as Audrey Griswold

Chevy Chase as Clark Griswold

Beverly D'Angelo as Ellen Griswold

Charlie Day as Chad

Catherine Missal as Adena

Ron Livingston as Ethan

Norman Reedus as Trucker

Keegan-Michael Key as Jack Peterson

Regina Hall as Nancy Peterson

Emyri Crutchfield as Sheila Peterson

Alkoya Brunson as Gary Peterson

Nick Kroll as Colorado Cop

Tim Heidecker as Utah Cop

Kaitlin Olson as Arizona Cop

Michael Peña as New Mexico Cop

Hannah Jeter as Ferrari Girl

David Clennon as Harry Co-Pilot

Colin Hanks as Jake

Kirstin Ford as Mom on Plane

Ethan Maher as Boy on Plane

Elizabeth Gillies as Heather

Cristina Squyres as Brooke

Nadine Avola as Chelsea

Ryan Cartwright as Terry

Valerie Payton as Shuttle Driver

O'Clair Alexander as Husky Lady at Monument

Miles Doleac as Man on the Monument

Holly Gardner as Women at Monument

R.F. Daley as Furious Husband

Elizabeth Fendrick as Furious Wife

Michael H. Cole as Male Guest

Brooke Jaye Taylor as Female Guest

Matthew Cornwell as Male Guest #2

Mitchell Warren as Wally World Kid #2

John Francis Daley as Ride Operator

Brandon Michael Hale as Gas Station Clerk (uncredited)

Libby Blake as Boobs (uncredited)

Rick Ericson as Hawaiian (uncredited)

Omar Lagudali as Reporter (uncredited)

Cameron McIntyre as Young James (age 7 / 9) (uncredited)

Jonathan Goldstein as Hot Tub Guy (uncredited)

John C. McGinley as Motorbike Cop