Winona Ryder as Susanna

Angelina Jolie as Lisa

Clea DuVall as Georgina

Brittany Murphy as Daisy

Elisabeth Moss as Polly

Jared Leto as Tobias Jacobs

Jeffrey Tambor as Dr. Potts

Vanessa Redgrave as Dr. Wick

Whoopi Goldberg as Valerie

Angela Bettis as Janet

Jillian Armenante as Cynthia

Drucie McDaniel as M-G

Alison Claire as Gretta

Christina Myers as Margie

Joanna Kerns as Annette

Travis Fine as John

Gloria Barnhart as Older Catatonic

Josie Gammell as Mrs. McWilley

Bruce Altman as Prof. Gilcrest

Mary Kay Place as Mrs. Gilcrest

Ray Baker as Mr. Kaysen

KaDee Strickland as Bonnie Gilcrest

Christian Monroe as Ronny

Kurtwood Smith as Dr. Crumble

David Scott Taylor as Cabby-Monty Hoover

Janet Greer as ER Nurse

Christopher Grimaldi as ER Resident

Ginny Graham as Arleen

Richard Domeier as Art Teacher

John Kirkman as Jack

Sally Bowman as Maureen

Misha Collins as Tony

John Lumia as Van Driver

Marilyn Brett as Italian Shop Keeper

Henry Alex Rubin as Josh

Marilyn Spanier as Miss Plimack

Linda Gilvear as Miss Paisley

Allen Strange as Principal

Spencer Gates as British Teacher

Rebecca Derrick as Lillian

Anne Connors as Nurse

Steve Altes as Medic

Joe Gerety as Cop

Anne Lewis as Dance Therapist

Donny Martino as Naked Man

John Levin as ER Doctor

Irene Longshore as Connie

Katie Rimmer as Tiffany

Jonathan Martin Spirk as Tough Guy