Leslie Nielsen as Frank Drebin

Priscilla Presley as Jane Spencer

Ricardo Montalban as Vincent Ludwig

George Kennedy as Ed Hocken

O. J. Simpson as Nordberg

Susan Beaubian as Mrs. Nordberg

Nancy Marchand as Mayor

Raye Birk as Pahpshmir

Jeannette Charles as Queen Elizabeth II

Ed Williams as Ted Olsen

Tiny Ron as Al

"Weird Al" Yankovic as 'Weird Al'

Leslie Maier as 'Weird Leslie'

Winifred Freedman as Stephanie

Joe Grifasi as Foreman

Tony Brafa as Enrico Pallazzo

Lorali Hart as Woman On Ledge

Nicholas Worth as Thug #1

Ronald G. Joseph as Thug #27

Doris Hess as Nurse #2

Charlotte Zucker as Dominique

Larry Pines as Drug Dealer #1

Tom Dugan as Drug Dealer #2

Burton Zucker as Photographer

David Katz as Arafat

Robert LuJane as Khadafi

Charles Gherardi as Khomeini

Prince Hughes as Idi Amin

David Lloyd Austin as Gorbachev

Ken Minyard as Ken & (voice)

Robert Arthur as Bob (voice)

Greg Breslau as Man Deleted from Fireworks Scene

Sharon Breslau as Woman Deleted from Fireworks Scene

Reggie Jackson as Angel Right Fielder

Michael J. Montes as Angel Shortstop

Charles Fick as Angel Catcher

Lawrence Tierney as Angels Manager

Hank Robinson as First Base Umpire

Joe West as Third Base Umpire

Jay Johnstone as Seattle First Up

Randy Harvey as Seattle Pitcher

Brett Bartlett as Seattle Centerfielder

Dennis Packer as Baseball P.A. Announcer

Dick Vitale as Baseball Announcer

Dick Enberg as Baseball Announcer

Jim Palmer as Baseball Announcer

Mel Allen as Baseball Announcer

Curt Gowdy as Baseball Announcer

Tim McCarver as Baseball Announcer

Joyce Brothers as Baseball Announcer

Don Woodard as "There he is!"

Christopher J. Keene as "Please disperse, Please disperse."

Mary Norman as "Here, you can use my radio mike."

Susan Breslau as "Hey, look out!"

Rick Seaman as "Ya dumb broad!"

Fredric Arnold as "Hey! What's the meaning of this?"

Ron Tank as "Mayor, will there be any additional security officers added to the police force during the Queen's visit?"

Mallory Sandler as "Oh, Dr. Alford, I have Mrs. Kepley's chart if you're ready to go over it."

Edwina Moore as "Mr. Pallazzo, our head usher will be here in two minutes to take you onto the field."

Jeff Wright as "Mr. Pallazzo! Would you come with me?"

Jim Smith as "Sorry, fellas."

Mark Holton as "It's Enrico Pallazzo!"

Jane Couris as "You killed him!"

John Houseman as Driving Instructor (uncredited)

Brinke Stevens as Brunette Woman in Showers (uncredited)

Jesse Ventura as Baseball Announcer (uncredited)

Bob Herron as Dr. Alford (uncredited)

Eddie Hice as Criminal at Police Station / Baseball Fan (uncredited)

Conrad E. Palmisano as Hijacked Taurus Driver (uncredited)